Clinical and laboratory characteristics of patients with obliterating atherosclerosis of the arteries of the lower extremities at ІІІА-B - IV stages of chronic arterial insufficiency and the risk of reperfusion-reoxygenative syndrome development.
DOI:
https://doi.org/10.11603/2414-4533.2018.4.9720Keywords:
reperfusion-reoxygenative syndrome, obliterating atherosclerosis, chronic arterial insufficiencyAbstract
The aim of the work: to study the clinical and laboratory characteristics of patients with obliterating atherosclerosis of major arteries at CAI ІІIA-B – IV stages in order to develop a system of prevention and treatment of reperfusion-reoxygenative syndrome development.
Matherials and Methods. The basis of the work is the analysis of complex examination and surgical treatment of 119 patients with obliterating atherosclerosis of aorta and trunk arteries of the lower extremities. Two groups of patients were distinguished. Group 1 consisted of 63 people with atherosclerotic lesions of the aorta and major arteries, CAI of IIIA-B –IV stages, group 2 – of 56 people with atherosclerotic lesion of major arteries, CAI of III-B-IV stages, which suspected possible development of reperfusion-reoxygenative syndrome after the revascularization of the major arteries of the lower extremities.
Results and Discussion. Patients from the group 2 of the study are characterized by long and high degree of chronic arterial insufficiency, severe inability of the collateral system of the lower extremity, high level of inflammatory response, expressed leukocyte index of intoxication, leukocyte shift index, high phagocytic activity of neutrophils, monocytes and their oxidative ability, activity of all groups of cytokines, increased activity of nonspecific proteinases and their inhibitors, increased activity of components of prooxidant-antioxidant system that not only activates the free radical mechanism, but also potentiates the processes of tissue damage, severe growing endothelial dysfunction.
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