Influence of experimental cranioskeletal trauma on the activity of lipid peroxidation processes in lungs of rats of different age

Abstract

The aim of the work: to find out the content of TBA-active LPO products in the lungs in the dynamics of early manifestations of cranio-skeletal trauma in individuals of different age groups.

Materials and Methods. Experiments were performed on nonlinear white male rats of three age groups (100–120 days, 6–8 months and 19–23 months). In experimental groups, a cranio-skeletal trauma, equivalent to animals of different age groups, was modeled under thiopental sodium anesthesia. The control group consisted of 7 animals of each age group, which were only injected into thiopental-sodium anesthesia. After 1, 3 and 7 days after injuries in the lungs of experimental animals, the activity of lipid peroxidation processes on the content of reagents to thiobarbituric acid (TBA-active products) was evaluated.

Results and Discussion. Studies showed that control animals of different age groups did not have statistically significant differences in the content of overproduct lipid peroxidation. After causing cranio-skeletal trauma in the acute period and early manifestations of traumatic illness, the content of TBA-active products with increasing age increased, indicating a more secondary lung injury in older animals and indicating age-related decline in the lung of the antioxidant reserve. The age-wise increase of lipoperoxidation processes in the lungs in response to cranio-skeletal trauma is a significant factor in the pathogenesis of their secondary lesion in the acute period and the period of early manifestations of traumatic illness, which should be taken into account when developing pathogenetically grounded correction methods.