Features of structural changes of the internal organs in patients with acute pancreatitis in conditions of polymorbidity

Authors

  • Ya. Ya. Bodnar ДВНЗ “Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України”1
  • I. Ya. Dziubanovskyi ДВНЗ “Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України”1
  • T. K. Golovata ДВНЗ “Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України”1
  • P. Ya. Bodnar ДВНЗ “Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України”1
  • N. O. Suslova ДУ «Інститут серця МОЗ України»2
  • L. P. Bodnar ДВНЗ “Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України”1

DOI:

https://doi.org/10.11603/2414-4533.2018.1.8856

Keywords:

internal organs, acute pancreatitis, polymorbidity.

Abstract

The aim of the work: to find out the regularities of the processes of internal organs remodeling of the dead from complicated pancre­atitis in conditions of polymorbidity.

Materials and Methods. A retrospective analysis of 163 protocols of autopsy and pathohistological examination of necropsies of the dead from acute surgical pathology was conducted. Among them, acute pancreatitis as the underlying disease was diagnosed in 30 people, that was 18.5 % of the total number of analyzed protoco ls.

Results and Discussion. Аccording to autopsy data, concomitant cardiovascular pathology was diagnosed, namely aortic atheroscle­rosis (73.3 %), IHD (60.0 %), arterial hypertension (60.1 %), chronic obstructive pulmonary disease (63.3 %) and endocrinopathy (23.3 %),) Overall, the polymorbidity index was 4.7. A complex of structural changes in the heart, kidneys, lungs, liver and adrenal glands are structural components of multiorgan failure in acute pancreatitis. Microscopic research has established that the constant component in the pathogenesis of polyogenetic insufficiency in acute pancreatitis is the presence of varying degrees of severity of circulatory disorders in all internal organs.

Author Biography

Ya. Ya. Bodnar, ДВНЗ “Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України”1

 

References

Bezrodnyi, B.H., Korotkyi, V.M., & Kolosovych, I.V., & Sydorenko, R.A. (2010). Khirurhichne likuvannia zakhvoriuvan pidshlunkovoi zalozy [Surgical treatment of pancreatic diseases]. Kyiv [in Ukrainian].

Zadnipryanyy, I.V., Tretyakova, O.S., & Satayeva T.P. (2015). Izmeneniya sokratitelnіkh kardiomiotsytov i gemomikrotsyrkulyatornogo rusla u beremennіkh i novorozhdennykh krіs v usloviyakh khemicheskoy gipoksii [Changes in contractile cardiomyocytes and hemocirculatory circulation in pregnant and newborn rats under conditions of hemic hypoxia]. Rossiyskiy mediko-biologicheskiy vestnik imeni akademika I.P. Pavlova – Russian Medical and Biological Journal named after academician I.P. Pavlov, 23, 2, 19-25 [in Russian].

Emelyanov, S.I., Bryskin, B.S., & Demidov, D.A. (2010). Khirurgicheskiy endotoksikoz kak problema klinicheskoy gastroenterologii [Surgical endotoxicosis as a problem of clinical gastroenterology]. Еksperimentalnaya i kiln. gastroenterologiya – Experimental and Clinical Gastroenterology, 7, 67-73 [in Russian].

Pokotylo, V.Yu., Haliuk, U.M., & Mateshuk-Vatseba, L.R. (2017). Morfolohichni osoblyvosti miokarda ta yoho mikrotsyrkuliatornoho rusla na svitlooptychnomu rivni za umov perebihu eksperymentalnoi opioidnoi intoksykatsii [Morphological features of the myocardium and its microcirculatory bed at the light-optical level under the conditions of the experimental opioid intoxication]. Visnyk problem biolohii i medytsyny – Bulletin of Biology and Medicine, 4, 2 (140) 123-128 [ in Ukrainian].

Svyrydiuk, V.Z. (2007). Alhorytm diahnostyky khronichnoho pankreatytu v polimorbidnykh patsiientiv [Algorithm for diagnosis of chronic pancreatitis in multimorbid patients]. Suchasna hastroenterolohiia – Modern Gastroenterology, 5 (37), 42-53 [in Ukrainian].

Styazhkina, S.N., Sytnikov, V.A., & Ledneva, A.V. (2011). Ostryy destruktivnyy, pankreatit: diagnostika i lecheniye [Acute destructive, pancreatitis: diagnosis and treatment]. Mezhdunarodnyy zhurnal prykladnikh i fundamentalnikh issledovaniy – International Journal of Applied and Fundamental Research, 5, 110 -112 [in Russian].

Shevchuk, I.M., Kuzenko, R.T., & Shevchuk, M.H. (2011). Profilaktyka hniino-septychnykh uskladnen hostroho nekrotychnoho pankreatytu u khvorykh pokhyloho ta starechoho viku [Prevention of purulent-septic complications of acute necrotic pancreatitis in elderly and senile patients]. Naukovyi visnyk Uzhhorodskoho universytetu, seriia “Medytsyna” – Scientific Herald of Uzhhorod University, series "Medicine", 2 (41), 294-297 [in Ukrainian].

Gardner, T.B., Vege, S.S., & Pearson, R.K. (2008). Fluid resuscitation in acute pancreatitis. Clin. Gastroenterol. and Hepatology, 6, 1070-1076.

Nathens, A.B., Curtis, J.R., & Beale, R.J. (2004) Management of the critically ill patient with severe acute pancreatitis. Crit. Care Med., 32, 2524-2536.

Takeda, K., Takada, T., & Kawarada, Y. (2006). JPN Guidelines for the management of acute pancreatitis: medical management of acute pancreatitis. J. Hepatobiliary Pancreat. Surg., 13, 42-47.

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Published

2018-05-05

How to Cite

Bodnar, Y. Y., Dziubanovskyi, I. Y., Golovata, T. K., Bodnar, P. Y., Suslova, N. O., & Bodnar, L. P. (2018). Features of structural changes of the internal organs in patients with acute pancreatitis in conditions of polymorbidity. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1), 5–9. https://doi.org/10.11603/2414-4533.2018.1.8856

Issue

No. 1 (2018)

Section

ORIGINAL INVESTIGATIONS

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