Features Of Oxygen-Dependent Processes In Rats With Acute Peritonitis With Underlying Merkazolil-Induced Hypothyroidism.
DOI:
https://doi.org/10.11603/2414-4533.2017.1.7628Keywords:
extensive peritonitis, hypothyroidism, oxygen-dependent processes.Abstract
The aim of the work: to study the impact of reduced production of thyroid hormones on the state of oxygen-dependent processes.
Materials and Methods. There were used Wistar albino rats. Hypothyroidism was simulated by the injection of Merkazolil at a dose of 25 mg / kg for 21 days. Acute peritonitis was simulated by the injection of 0.5 ml of 10% filtered fecal suspension into the abdominal cavity of studied animals. We determined the ratio of phagocytic cells at the site of injury, production of active oxygen species by the system of phagocytic mononuclears, spontaneous and induced nitroblue tetrazolium test (NBT-test).
Results and Discussion. The study revealed that the presence of hypothyroidism in experimental animals, with simulated acute fecal peritonitis was accompanied by violation of the ratio of phagocytic cells at the site of injury, less pronounced than in euthyroid rats, increasing of active oxygen species and indicators of spontaneous and induced NBT test and, consequently, reduction of their intensity in production of active oxygen species. In the conditions of hypothyroidism oxygen-dependent biocidal activity of neutrophils and functional reserves of phagocytic cells is decreased.
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