Experimental Research Of Efficient Use Of Barrier Methods For Preventing Adhesions In The Abdominal Cavity

Authors

  • V. V. Bukata I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/2414-4533.2017.1.7337

Keywords:

adhesive peritoneal disease, defensal, prevention of adhesion formation.

Abstract

Objective: To determine the effectiveness of the drug "Defensal" to prevent formation of adhesions in experimental conditions

Materials in Methods: Laboratory studied 84 sexually mature male albino rats weighing 172-180 g, which were divided into 8 groups. Group 1 consisted of six experimental animals that were in common vivarium conditions; in group 2, laparotomy was  performed on 6 rats; 3rd, 4th and 5th group - 12 experimental animals modeled adhesive disease with euthanasia on the 4th, 10th and 30th day of the disease respectively; in 6th, 7th and 8th Group - a research on 12 rats which modeled adhesive disease using “defensal” was done euthanasia on the 4th, 10th and 30th day of the experiment, respectively.

Results and discussion: complex morphological techniques used used (macroscopic, histological, morphometry) in the dynamics of adhesions. The research and findings indicated that the drug "Defensal" had positive impact on the course of experimental adhesive disease. In the last correction it was indicated that the drugs were used on abdominal cavity of experimental animals significantly reduced the number of visceral-parietal and parietal-parietal adhesion, most of them formed threadlike, loose, tends to decrease the thickness in the dynamics of the disease, and did not easily deformed hollow organs of the digestive system and did not affect their function. These solderings were rarely observed in vessels and nervous elements. These data confirmed the efficacy of the drug "Defensal" as a barrier method of prevention of adhesion formation, allowing safe usage of proposed tool in clinical practice.

Author Biography

V. V. Bukata, I. Horbachevsky Ternopil State Medical University

Senior assistant of General Surgery

References

Kozlov, O.A., & Troyan V.V. (2007). Laparoscopicheskie technologii v diagnostike i lechenii spaechnoy kishechnoy neprohodimosti i spaechnoi bolezni u detei: uchebno-metodicheskoe posobie [Laparoscopic technologies in the diagnosis and treatment of adhesive intestinal obstruction and adhesions in children: teaching aid]. Minsk [in Russian].

Matveev, N.L., & Arutunyan, D.U. (2007) Vnytribrushinie spayki – nedootsenivayemaya problema (obzor literatury). [Intra-abdominal adhesions –an underestimated problem (literature review)]. Endoscopicheskaya khiryrgiya – Endoscopic Surgery, 5, 60-69 [in Russian].

Operative Laparoscopy Study Group: Postoperative adhesion development after operative laparoscopy: Evaluation at early second-look procedures. Fertil. Steril., 55, 700-704.

Popov, A.A., & Manannikova, T.N. (2012). Profilaktika spaechnogo protsessa posle ginekologicheskikh operatsyi [Prevention of adhesions after gynecological operations]. Rossiyskiy vestnik akushera-ginekologa – Russian Journal of Obstetrician-Gynecologist, 3, 24-30 [in Russian].

Sykovatykh, B.S., Zhykovskiy, V.A., Lipatov, V.A., & Blinkov, Yu.Yu. (2014). Sovremennye tekhnologii profilaktiki posleoperatsyonnogo spaykoobrazovaniya [Modern technologies for the prevention of postoperative adhesions]. Vestnik khiryrgii – Journal of Surgery, 173 (5), 98-104 [in Russian].

Verkhuletskiy, I.E. (2009). Aspekty morfologii i klassifikatsii spaechnogo protsessa organov brushnoy polosti [Aspects of morphology and classification of the adhesive process of the abdominal organs]. Ukrainskyi zhurnal khirurhii – Ukrainian Journal of Surgery, 3, 30-33 [in Russian].

Slonetskyi, B.I., & Onyshchenko, S.M. (2010). Hostra spaikova kyshkova neprokhidnist: problemy ta perspektyvy diahnostyky na rannomu hospitalnomu etapi [The acute adhesive intestinal obstruction: problems and prospects diagnosis of early hospital stage]. Medytsyna nevidkladnkhx staniv – Medicine of Emergency States, 6 (31). Retreived from: http://www.mif-ua.com./archive/article_print/15117 [in Ukrainian].

Bondarev, R.V., & Orekhov, A.A. (2008). Laparoskopicheskie vmeshatelstva pri ostroi spaeechnoy kishechnoy neprokhodimosti [Laparoscopic interventions for acute adhesive intestinal obstruction] Vestnik neotlozhnoy i vosstanovitelnoy meditsyny – Journal of Emergency and Recovery Medicine, 9 (3), 335-337 [in Russian].

Gorelik, P.V. & Makshanov, I.Ya. (Eds.). (2000). Spaechnaya kishechnaya neprokhodimost. Patogenez diagnostika taktika lechenie profilaktika: metod. rekom. [Adhesive intestinal obstruction. Pathogenesis diagnosis, tactics, treatment prevention: method. recommendations]. Grod. gost. med. in-t [in Russian].

Ksionz, I.V. Klinichna efektyvnist zastosuvannia antyadhezyvnykh zasobiv pry likuvanni ta profilaktytsi zlukovoi kyshkovoi neprohidnosti u ditei [Clinical efficacy anti-adgesive means in the treatment and prevention of adhesive intestinal obstruction in children]. Aktualni problemy suchasnoi medytsyny – Actual Problems of Modern Medicine, 15 (51), 125-129 [in Ukrainian].

Lazarenko, V.A., Skovatykh, B.S., & Bezhyn, A.I. (2001) Pervyi opyt primineniya protivospaechnogo rassasyvaushchegosya polimernogo sredstva “Mezogl” pri ostrom appendetsite [First experience of application of adhesion absorbable polymer drug "Mezogl" at acute appendicitis] Kurskiy nauchno-prakticheskiy vestnik “Chelovek i ego zdorove” – Kursk Scientific-Practical Journal “Man and his healh”, 1, 51-55 [in Russian].

Pyptiuk, O.V., Telemukha, S.B., & Maliutin, O.M. (2015). Kompleksne likuvannia zlukovoi khvoroby ocherevyny z vykorystanniam preparatu “DEFENSAL” (Pershyi dosvid) [Comprehensive treatment of adhesive peritoneal disease using the drug "DEFENSAL" (first experience)]. Khirurhiia Ukrainy – Surgery of Ukraine, 1, 68-72 [in Ukrainian].

Attard, J.A., & MacLean, A.R. (2007) Adhesive small bowel obstruction: epidemiology, biology and prevention. Can. J. Surg., 4, 291-300.

Evtushenko, D.A. (2015). Profilaktika retsediva ostroi spaechnoy neprokhodimosti kishechnika [Prevention of recurrence of acute adhesive intestinal obstruction]. Kliinichna khirurhiia – Clinical Surgery, 10, 22-24 [in Russian].

Downloads

Published

2017-06-19

How to Cite

Bukata, V. V. (2017). Experimental Research Of Efficient Use Of Barrier Methods For Preventing Adhesions In The Abdominal Cavity. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1), 58–64. https://doi.org/10.11603/2414-4533.2017.1.7337

Issue

No. 1 (2017)

Section

EXPERIMENTAL INVESTIGATIONS

License

Authors who publish their work in Hospital Surgery. Journal by L. Ya. Kovalchuk agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  
  2. Лицензия Creative Commons
  3. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)