THE EVOLUTION OF CYTOPATHIC HYPOXIA AND CYTOKINE PROFILE DEPENDING ON THE STAGE OF PURULENT PERITONITIS

Authors

  • S. I. SAVOLYUK
  • M. A. HUDZ
  • V. A. KATSAL

DOI:

https://doi.org/10.11603/2414-4533.2016.2.6405

Abstract

A comparative analysis of the contents of cytokines and indicators cytopathic hypoxia (hemoglobin compounds pool –
carboxyhemoglobin and methemoglobin) in the blood of patients with purulent peritonitis (PP) of the defi nition of their diagnostic
value in determining the severity of peritonitis and choosing perioperative tactics. Level of IL-1, IL-2, IL-4, IL-6, TNF-α during
hospitalization in 126 patients PP was determined. It was stated that with progression stages PP (reactive and toxic) patients
had a progressive increase of proinfl ammatory cytokines (TNF-α, IL-1, IL-6 and IL-2) and anti-infl ammatory cytokine IL-4,
in patients with terminal stage, sharp reduce the concentration of IL-2, IL-4, IL-6 was determined, with continued growth
levels of IL-1, TNF-α. Research of COHb and MtHb levels showed a progressive increase in the progression of PP. Defi nition
of indicators cytokine profi le and cytopathic hypoxia showed high diagnostic value in determining the severity of the PP. High
cost, duration and technical complexity make it impossible for daily use cytokine profi le indicators in clinical work, while the
determination markers of cytopathic hypoxia (COHb, MtHb) as method of determining the severity of peritonitis is possible
for all levels of surgical departments.

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Published

2016-05-21

How to Cite

SAVOLYUK, S. I., HUDZ, M. A., & KATSAL, V. A. (2016). THE EVOLUTION OF CYTOPATHIC HYPOXIA AND CYTOKINE PROFILE DEPENDING ON THE STAGE OF PURULENT PERITONITIS. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (2). https://doi.org/10.11603/2414-4533.2016.2.6405

Issue

No. 2 (2016)

Section

ORIGINAL INVESTIGATIONS

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