Role of violations microsomal detoxification system in the pathogenesis of abdominal sepsis

Authors

  • M. S. Antonova ДВНЗ "Тернопільський державний медичний університет імені І.Я. Горбачевського МОЗ України"

DOI:

https://doi.org/10.11603/2414-4533.2016.1.5872

Abstract

In experiment on white rats-males of Vistar line in weight of 200–250 g simulated a 30-minute ischemia/reperfusion of distal part of small intestine, investigated a condition of monooxygenase and reductase chains of microsome of hepatocytes endoplasmic reticulum. Decrease of all studied parameters microsomal oxidations in early terms investigation (72 hour), against the intensity growth of lipid peroxidation testifies about malfunction of detoxication liver functions. Preliminary abdominal introduction of glucoproteides a-globulin fraction of human serumand carnitine to modeling ischemia/reperfusion of the small intestine protect cytochromes P-450 and b5 from oxidative damage, support the active functioning of the electron transport chain, contributing to improved energy cells by reducing the rate of lipid peroxidation and changes in endogenous respiration rate.

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Published

2016-03-01

How to Cite

Antonova, M. S. (2016). Role of violations microsomal detoxification system in the pathogenesis of abdominal sepsis. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1). https://doi.org/10.11603/2414-4533.2016.1.5872

Issue

No. 1 (2016)

Section

EXPERIMENTAL INVESTIGATIONS

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