The corellation of immunodependent mechanisms and Glutathione-S-Transferase Producing Gene Deletions in endomitriosis

Authors

  • L. M. Malanchuk
  • V. M. Martinyuk

DOI:

https://doi.org/10.11603/2414-4533.2015.4.5669

Abstract

The article is devoted to the actual problem today - the study of the relationship immunodependent mechanisms of gene deletion glutathione-S-transferase in a brilliant development of endometriosis. Gene network of this disease is rather complicated and diverse. It includes various genes metabolism (detoxification), genes that are responsible for immune status of genes and cell-cell interactions. Polymorphism of genes of detoxification often influences the functional activity of the molecular structure of DNA. In recent years in world literature there is more data to the pathological processes in the human body is due to immune regulation and characterized by a certain imbalance of pro- or anti-inflammatory cytokines, which contribute to the occurrence of endometriosis and can influence the effectiveness of treatment.

References

A possible mechanism of autoimmune-mediated infertility in women with endometriosis / J. Inagaki, L. Hao, M. Nakatsuka [et al.] // Am. J. Reprod. Immunol. – 2011 – Vol. 66(2) – P. 90-99

Adenomyosis: epidemiological factors. / P. Vercellini, P. Viganò, E. Somigliana [et al.] // Best Pract. Res. Clin. Obstet. Gynaecol. – 2006 – Vol. 20(4) – P. 465–477.

Glutathine S-transferase Ml gene polymorphisms and susceptibility to endometriosis in a French population / H. Baranova, R. Bothorishvilli, M. Canis [et al.] // Mol. Hum. Reprod. – 1997. – Vol. 3. – № 9. – P. 775–780.

Glutathione-S-transferase PI gene polymorphism and susceptibility to endometriosis / D. Ertunc, M. Aban, E. C. Ток [et al.] // Hum. Reprod. 2005.

Guo S. W. Epigenetics of endometriosis / S. W. Guo // Mol. Hum. Reprod. – 2009 – Vol. 15(10) – P. 587–607.

Haider S. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. / S. Haider, M. Knofler // Placenta. – 2009. – Vol. 30 – P. 111–123.

Berkkanoglu M. Immunology and endometriosis / M. Berkkanoglu, A. Arici // Am. J. Reprod. Immunol. – 2003. – Vol. 50. –P. 48–59.

Immunological factors and their role in the genesis and development of endometriosis / C. Siristatidis, C. Nissotakis, C. Chrelias [et al.] // J. Obstet. Gynaecol. Res. – 2006 – Vol. 32(2) – P. 162–170.

Published

2016-01-24

How to Cite

Malanchuk, L. M., & Martinyuk, V. M. (2016). The corellation of immunodependent mechanisms and Glutathione-S-Transferase Producing Gene Deletions in endomitriosis. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (4). https://doi.org/10.11603/2414-4533.2015.4.5669

Issue

Section

EXPERIENCE OF WORK