DYNAMICS OF ENDOGENOUS INTOXICATION BIOCHEMICAL MARKERS IN PATIENTS WITH ACUTE SMALL INTESTINAL OBSTRUCTION

Authors

DOI:

https://doi.org/10.11603/2414-4533.2025.4.15764

Keywords:

acute intestinal obstruction, endotoxicosis, surgical tactics, surgical intervention

Abstract

The aim of the work: to evaluate the dynamics of biochemical markers of endogenous intoxication in patients with acute small bowel obstruction before and after surgical treatment, depending on the stage of intestinal obstruction compensation.

Materials and Methods. The treatment outcomes of 221 patients with acute small intestinal obstruction. All patients underwent comprehensive clinical and laboratory examinations. The severity of endogenous intoxication was evaluated based on the dynamic changes in creatinine, urea, and middle molecular weight molecules in the preoperative and early postoperative periods.

Results. It was established that the severity of endogenous intoxication increased with the progression of acute small intestinal obstruction. The most pronounced changes in biochemical indicators were observed in patients at the decompensation stage. After surgical treatment, a positive trend toward a reduction in endotoxicosis manifestations was noted in all groups; however, in patients with severe disease, complete normalization of the indicators was not achieved in the early postoperative period.

Conclusions. The dynamics of endogenous intoxication indicators reflect the severity of acute small intestinal obstruction and can be used to assess the effectiveness of surgical treatment and to predict the postoperative course.

Author Biographies

V. V. BENEDYKT, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

DSc (Medicine), Professor of the Department of Surgery, Faculty of Postgraduate Education, Higher Education Institution

V. M. BAHRII, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

Postgraduate Student of the Department of Surgery, Faculty of Postgraduate Education, Higher Education Institution

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Published

2025-12-30

How to Cite

BENEDYKT, V. V., & BAHRII, V. M. (2025). DYNAMICS OF ENDOGENOUS INTOXICATION BIOCHEMICAL MARKERS IN PATIENTS WITH ACUTE SMALL INTESTINAL OBSTRUCTION. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (4), 97–101. https://doi.org/10.11603/2414-4533.2025.4.15764

Issue

No. 4 (2025)

Section

EXPERIENCE OF WORK

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Copyright (c) 2025 В. В. БЕНЕДИКТ, В. М. БАГРІЙ

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