REVIEW OF PROBIOTIC-BASED PREPARATIONS AND THEIR EFFICACY IN THE TREATMENT OF SURGICAL WOUNDS
DOI:
https://doi.org/10.11603/2414-4533.2024.4.15065Keywords:
infected wounds, probiotics, topical treatmentAbstract
The aim of the work: to compare the efficacy of probiotic-based preparations in treating infected wounds versus traditional methods. It focuses on scientific studies and clinical trials demonstrating probiotics’ potential to reduce inflammation, regulate the wound microbiome, and improve healing processes.
Materials and Methods. For this review, scientific publications were searched in PubMed, Google Scholar, our clinic’s data, and other academic resources. Key words included «probiotics», «infected wounds», «wound treatment», «microbiome», and «clinical trials». Articles on the use of probiotics in treating infected wounds and their impact on healing were selected and analyzed.
Results. Probiotics play a multi-level role in the wound healing process. Their main functions include modulating the immune response, regulating the wound microbiome, combating pathogenic microorganisms, and promoting tissue regeneration. Additionally, probiotics can complement traditional antibiotic therapy by reducing the risk of antibiotic-resistant infections. By modulating the skin microbiome and regulating local immunity, probiotics combined with antibiotics provide a synergistic effect in combating pathogens. In 35 cases where probiotics were used for injuries involving both soft tissues and bones, including traumatic limb amputations with burns, probiotic treatment showed dynamic effectiveness in staging the reparative processes of wounds and improving clinical outcomes.
Conclusions. The literature review indicates that probiotics effectively inhibit pathogens, reduce infection risks, and accelerate wound healing. No side effects were observed. These findings underscore the multi-faceted role of probiotics in wound healing.
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