CHOLESTEROL AS A CLINICAL AND LABORATORY MARKER OF METABOLIC DISORDERS IN PATIENTS WITH ISCHEMIC HEART DISEASE OF DIFFERENT AGE GROUPS
DOI:
https://doi.org/10.11603/2414-4533.2024.3.14925Keywords:
hypercholesterolemia, lipid metabolism, statins, WHO age classification, gender characteristicsAbstract
The aim of the work: to study the frequency of hypercholesterolemia and the use of statins in patients with coronary artery disease of different age groups, taking into account gender characteristics.
Materials and Methods. The study included patients with coronary heart disease who underwent coronary bypass surgery on a working heart (n=3674), both males (n=3061) and females (n=613), the average age of the study participants was 60.6±0.8 years. The material for the analysis was the data of a clinical laboratory study of biological fluid – blood. The research design is based on the patient's age group according to the age classification of the WHO and the patient's gender.
Results and Discussion. It was established that the highest cholesterol levels were in the "middle age" age group, both in men – 3.54 mmol/l, and in women – 3.89 mmol/l. It was found that the frequency of hypercholesterolemia was significantly higher in female patients compared to the corresponding frequency in men, p=0.0001, χ2=14.48. The highest frequency of hypercholesterolemia was observed in patients of the "middle age" age group, and in male patients its frequency was significantly lower than in female patients of the same age group, p=0.0001, χ2=18.08. It was established that with increasing age and taking into account the gender of the patients, there was a significant physiological decrease in the frequency of hypercholesterolemia. It was determined that statins were used significantly more often by female patients – 49.4%, compared to the corresponding frequency in male patients – 32.2 %, p=0.0001, χ2=73.89. It was also found that women with coronary heart disease were significantly more likely to use statins in all age groups compared to men.
Conclusions. As a result of the study, it was found that cholesterol levels remain a reliable clinical and laboratory marker for detecting metabolic disorders in patients with coronary artery disease. It was determined that the highest cholesterol levels were recorded in middle-aged patients of both sexes. Hypercholesterolemia is also significantly more common in the "middle-aged" age group, and taking into account gender, it is significantly more common in patients with coronary artery disease. It was determined that with age there is a significant decrease in the level of cholesterol, regardless of taking statins.
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