SIDE EFFECTS OF PROTON PUMP INHIBITORS IN THE CASE OF THEIR ROUTINE USE IN INTENSIVE CARE UNITS.
DOI:
https://doi.org/10.11603/2414-4533.2024.2.14856Keywords:
proton pump inhibitors, severe brain injuryAbstract
The aim of the work - to compare the incidence of nosocomial pneumonia, acute kidney injury and diarrhea caused by Clostridium difficile in patients with severe head injury and sepsis depending on the use of omeprazole.
Materials and Methods. 200 patients with severe TBI who were on prolonged mechanical ventilation were examined. Half of them received proton pump inhibitors, the other half did not.
The primary endpoints of the study (serious adverse events) were: • 28-day mortality, and • frequency of gastrointestinal bleeding during the study.
Secondary endpoints of the study (adverse events) were: • frequency of acute kidney injury, • frequency of diarrhea caused by confirmed Clostridium difficile infection, • incidence of ventilator-associated pneumonia.
Results. Prophylactic use of omeprazole in the routine treatment of sepsis after surgery for severe head injury increases the likelihood of ventilator-associated pneumonia, acute kidney injury, and clostridial infection, which may be the cause of increased mortality.
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