STRUCTURAL CHANGES OF THE LIVER IN PATIENTS OF DIFFERENT AGE GROUPS DEPENDING ON THE DURATION OF OBSTRUCTIVE JAUNDICE
DOI:
https://doi.org/10.11603/2414-4533.2024.2.14842Keywords:
obstructive jaundice, liver biopsy, morphological study of liverAbstract
The aim of the work: to study structural changes of the liver depending on the duration of obstructive jaundice (OJ) in patients of different age groups.
Materials and Methods. 50 OJ patients were subdivided into two groups. Group I (n=25) consisted of young (18-44-year-old) and middle-aged patients (45-59-year-old), while the Group II (n=25) included elderly (60-74-year-old) and senile patients (75-90-year-old). In each group, there were 5 subgroups of patients with different duration of OJ: less than 7 days, 7-14 days, 14-21 days, 21-28 days, and over 28 days.
Results and Discussion. In the Group I patients with duration OJ up to 7 days and 7-14 days, and in the Group II patients with OJ lasting up to 7 days, morphological changes in the liver had mainly a reverse course and consisted of: intraductal cholestasis, inflammatory infiltration of the stroma, and dystrophy of hepatocytes. In case of OJ duration 14-21 days and 21-28 days in the Group I patients, and in the Group II patients with OJ lasting for 7-14 days and 14-21 days, the changes in the liver had both reversible and irreversible course and were associated with intraductal and intracellular cholestasis, reactive hepatitis, severe dystrophy, small focal necrosis of hepatocytes, and initial fibrosis. In case of OJ duration over 28 days in the Group I patients and in the Group II patients with OJ lasting for 21-28 days and over 28 days, we was observed the irreversible morphological hepatic changes which consisted of multiple diffuse extra- and intracellular bilirubin deposits, large focal necrosis of hepatocytes, severe fibrosis, and development of liver cirrhosis.
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