Quantitative morphological study of the features of the structural reconstruction of the hemomicrocirculatory bed of the prostate at postresection portal hypertension
DOI:
https://doi.org/10.11603/2414-4533.2023.3.14152Keywords:
prostate, hemomicrocirculatory bed, postresection portal hypertensionAbstract
The aim of the work: using quantitative morphological methods to study the features of the structural reconstruction of the hemomicrocirculatory bed of the prostate in the conditions of postresection portal hypertension.
Materials and Methods. The hemomicrocirculatory bed of the prostate of 15 intact white rats, 30 animals with postresection portal hypertension, and 17 rats with a combination of postresection portal hypertension with multiple organ failure was morphologically investigated. Animals were euthanized by bloodletting under thiopental anesthesia 30 days after the beginning of the experiment. The diameters of arterioles, precapillary arterioles, hemocapillaries, postcapillary venules, venules, and the density of microvessels per 1 mm² of tissue of the organ under study were determined on histological micropreparations of the prostate. Quantitative values were processed statistically.
Results and Discussion. Morphologically, it was established that the removal of the left and right lobes of the liver lead to the development of postresection portal hypertension and pronounced remodeling of the blood vessels of the hemomicrocirculatory bеd of the prostate, which was characterized by a pronounced narrowing of the lumen of arterioles by 21.5 %, precapillary arterioles by 32.4 %, hemocapillaries by 19.1 %, when portal hypertension is combined with multiorgan failure – by 25.6; 35.3 and 22.4 %, respectively. Capillary venules in postresection portal hypertension expanded by 36.5 %, venules by 30.5 %, the density of microvessels decreased by 25.5 %, with the development of multiple organ failure – by 38.5 %,; 32.7 and 28.4 % respectively.
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