Dynamics of changes in markers of endogenous intoxication in rats with simulating acute generalized peritonitis on a background of obesity
DOI:
https://doi.org/10.11603/2414-4533.2023.3.14150Keywords:
acute generalized peritonitis, obesity, endogenous intoxicationAbstract
The aim of the work: to study the state of indicators of endogenous intoxication in the body of experimental animals with simulated AGP on the background of obesity and to compare them with groups of animals with obesity and with animals with AGP.
Materials and Methods. The experiment used 64 white Wistar rats, which were divided into three groups: the main group – 24 animals with AGP modeling against the background of obesity; the comparison group – 8 animals with modeling of obesity only; another comparison group – 24 animals with only AGP simulation; the control group consisted of 8 intact animals kept in standard vivarium conditions. АPP was modeled by injecting 10 % filtered fecal suspension into the abdominal cavity. Obesity was simulated using a high-calorie diet. The content of indicators of endogenous intoxication in the blood of animals was determined using the photospectrometric method.
Results and Discussion. It was established that in animals with АGP against the background of obesity, the indicators of lipoperoxidation were significantly activated (by 1.8 times the level of TBА-AP compared to intact animals) and the antioxidant defense was depleted (according to a statistically significantly lower index of superoxide dismutase by 2.4 times compared to the control) ) (p <0.05).
Conclusions. The development of AGP is accompanied by the EIS complex, which indicates an increase in catabolic processes in the dynamics of pathology modeling, and is laboratory-detected by a probable increase in the levels of MSM, EII. The depth of endotoxemia in rats increases during all stages of development of acute peritonitis and depends on the presence of accompanying obesity, which is confirmed by significantly higher levels of MM254 and MM280, EII during all observed terms of animals with combined pathology.
References
Nascimbeni, R., Amato, A., Cirocchi, R., Serventi, A., Laghi, A., Bellini, M., ... & Binda, G.A. (2021). Management of perforated diverticulitis with generalized peritonitis. A multidisciplinary review and position paper. Techniques in Coloproctology, 25, 153-165. DOI: https://doi.org/10.1007/s10151-020-02346-y
Bridoux, V., Regimbeau, J.M., Ouaissi, M., Mathonnet, M., Mauvais, F., Houivet, E., ... & Tuech, J.J. (2017). Hartmann’s procedure or primary anastomosis for generalized peritonitis due to perforated diverticulitis: a prospective multicenter randomized trial (DIVERTI). Journal of the American College of Surgeons, 225(6), 798-805. DOI: https://doi.org/10.1016/j.jamcollsurg.2017.09.004
Mattos, A.A., Wiltgen, D., Jotz, R.F., Dornelles, C.M., Fernandes, M.V., & Mattos, Â.Z. (2020). Spontaneous bacterial peritonitis and extraperitoneal infections in patients with cirrhosis. Annals of hepatology, 19(5), 451-457. DOI: https://doi.org/10.1016/j.aohep.2020.04.010
Choua, O., Ali, M.M., Kaboro, M., Moussa, K.M., & Anour, M. (2017). Etiological, clinical, and therapeutic aspects of acute generalized peritonitis in N’Djamena, Chad. Medecine et Sante Tropicales, 27(3), 270-273. 5. Acosta, S. (2014). Surgical management of peritonitis secondary to acute superior mesenteric artery occlusion. World Journal of Gastroenterology, 20(29), 9936-41. DOI: https://doi.org/10.1684/mst.2017.0696
Bradshaw, T., & Mairs, Н. (2014). Obesity and serious mental ill health: a critical review of the literature. Healthcare, 2, 166-182. DOI: https://doi.org/10.3390/healthcare2020166
Konovchuk, V., Andrushchak, A., Kushnir, S., Maksymiuk, V., & Kokalko, M. (2022). The state of toxin-releasing function of the kidneys in the syndrome of endogenous intoxication of purulent-septic origin in patients with diabetes mellitus. Wiadomości Lekarskie, 75(7), 1724-1727. DOI: https://doi.org/10.36740/WLek202207121
Kondratyuk, M.O., Sorokopud, O.O., Strіl’chuk, L.M., Zhakun, І.B., & Slaba, O.R. (2019). Chronic heart failure course prognosis depending on body weight and endogenous intoxication syndrome. Wiadomości Lekarskie, 72(4), 527-531. DOI: https://doi.org/10.36740/WLek201904104
Krynytska, I., Marushchak, M., Svan, O., Akimova, V., & Mazur, L. (2018). The indices of endogenous intoxication in rats with carrageenan solution consumption. Georgian Med News, 279, 196-200.
Sfera, A., Osorio., C, Jafri, N., Diaz, E.L., & Campo Maldonado, J.E. (2020). Intoxication With Endogenous Angiotensin II: A COVID-19 Hypothesis. Frontiers in Immunology, 11, 1472. DOI: https://doi.org/10.3389/fimmu.2020.01472
Lazarenko, V.A., Lipatov, V.A., Blinkov, Yu.Yu., & Skorikov, D.V. (2008). Eksperimentalnaya model rasprostranennogo kalovogo peritonita [Experimental model of widespread fecal peritonitis]. Chelovek i yego zdorovye – Man and his health, 4, 128-132 [in Russian].
Habryelian, N.Y., & Lypatova, V.Y. (1984). Opredelenye soderzhanyia srednemolekuliarnykh peptydov v krovy [Determination of the content of medium molecular peptides in the blood]. – Laboratory Work, 3, 138-140 [in Russian].
Togaybayev, A.A., Kurguzkin, A.V., Rikun, I.V. (1988). Metod opredeleniya endogennoy intoksikatsii [Method for the determination of endogenous intoxication]. Laboratornoye delo – Laboratory Work, 9, 22-24 [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 I. M. KLISHCH, N. M. MALEVYCH, Z. M. NEBESNA
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish their work in Hospital Surgery. Journal by L. Ya. Kovalchuk agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
