Radiologic and morphometric criteria of osteoporotic changes in patients with diffuse large b-cell lymphoma
DOI:
https://doi.org/10.11603/2414-4533.2023.3.14113Keywords:
computed tomography, morfometry, bone mineral density, osteoporosis, diffuse large B-cell lymphomaAbstract
The aim of the work: to develop radiologic and morphometric criteria for osteoporotic changes in patients with lymphomas undergoing chemotherapy courses.
Materials and Methods: The results of the examination and treatment of 115 patients with diffuse large B-cell lymphoma were analyzed. The average age was (57.86±1.40) years. The determination of bone mineral density of the lumbar vertebrae (L1–L5) was performed in Hounsfield units in a bone window using axial computed tomography images at the diagnostic stage and after completing chemotherapy courses. Morphometric measurements of the anterior, posterior, and middle vertebral body heights were determined using sagittal computed tomography slices.
Results and Discussion. At the diagnostic stage, normal bone mineral density was found in 26.09 % of patients, osteopenia in 52.17 %, and osteoporosis in 21.74 %. In men, the average values were characteristic of normal bone density, while in women, osteopenia predominated. After completing chemotherapy, normal bone density was found in 16.52 % of patients, osteopenia in 29.57 %, and osteoporosis in 53.91 %. In men, the average values corresponded to osteopenic changes, while in women, it indicated osteoporosis. Morphometric analysis at the diagnostic stage revealed deformations of the vertebral bodies in 22.61 % of patients: moderate deformation in 12.17 %, moderate in 6.96 %, severe in 3.48 %. An increase in the number of vertebral body deformations was observed in 53.85% of patients after treatment. Comparative assessment of structural and functional parameters of bone tissue depending on the treatment protocol showed a significant decrease in indicators by 24.49 % for the CHOP protocol and 21.25 % for the R-CHOP protocol. X-ray and morphometric criteria for osteoporotic changes in bone tissue have been developed for early diagnosis of osteoporosis and preventive measures in oncohematological patients.
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