Analysis of wound planimetry indicators using different methods of influence on the wound process in the experiment

Authors

  • M. Yu. Kritsak I. Horbachevsky Ternopil National Medical University
  • M. Aljehani Naif Abdulelah I. Horbachevsky Ternopil National Medical University
  • I. Ya. Dziubanovskyi I. Horbachevsky Ternopil National Medical University
  • Yu. M. Futuima I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2023.2.13992

Keywords:

diabetes, venous hypertension, wound model, area of the wound

Abstract

The aim of the work: to analyze the parameters of planimetry in rats with different methods of influence on the wound process separately with venous and diabetic etiology.

Materials and Methods. The work was performed on 57 white sexually mature rats of both sexes with an initial weight of (220±12) g. The animals were divided into 6 groups, which were modeled wounds separately for diabetic etiology and venous etiology. Type 1 diabetes was simulated by intravenous administration of alloxan (15 mg/kg), confirmed after 14 days by assessment of glycemia (more than 12 mmol/l). Venous hypertension was simulated by ligation of the femoral vein below the inguinal ligament.

Results and Discussion. When analyzing the course of the wound process in diabetes, it was established that the course is slower than in venous etiology, the best results were obtained when using debridement with injections of platelet-rich plasma into the wound. Thus, on the 14th day, the wound area in the third group was the smallest and was 2 times smaller compared to the initial area, 1.1 times smaller than in the group where only wound debridement was used and 1.3 times smaller in the group using classical methods of influencing the wound process. With venous pathology, on the 14th day, the sixth group had the smallest wound area, which decreased by 70.8 % (from 400 to (117±8.2) mm2) compared to the initial data, by 33.6 % (from (176 ±11.6) to (117±8.2) mm2) than in the fifth group, by 47.6 % (from (223±8.7) to (117±8.2) mm2) less than in the fourth group and by 41.8 % (from (201±10.2) to (117±8.2) mm2) than in the similar group with diabetes.

References

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Published

2023-07-25

How to Cite

Kritsak, M. Y., Aljehani Naif Abdulelah, M., Dziubanovskyi, I. Y., & Futuima, Y. M. (2023). Analysis of wound planimetry indicators using different methods of influence on the wound process in the experiment. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (2), 43–48. https://doi.org/10.11603/2414-4533.2023.2.13992

Issue

No. 2 (2023)

Section

EXPERIMENTAL INVESTIGATIONS

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