Morphometric aspects of the prostate arterial bed remodeling in the conditions of postesection portal hypertension
DOI:
https://doi.org/10.11603/2414-4533.2023.1.13809Keywords:
postresection portal hypertension, prostate gland, arteriesAbstract
The aim of the work: to investigate the peculiarities of the prostate arterial bed remodeling in the conditions of postresection portal hypertension.
Materials and Methods. The arterial bed of the prostate gland of 62 white rats, which were divided into 3 groups, was studied. Control group 1 – 15 intact animals, 2 – 30 rats with postresection portal hypertension, 3 – 17 animals with postresection portal hypertension combined with multiple organ failure. Animals were euthanized by bloodletting under thiopental anesthesia 30 days after the beginning of the experiment. The outer and inner diameters of medium and small-caliber arteries, the thickness of the media, adventitia, Vogenvoort, Kernogan indices, the height of endotheliocytes, the diameter of their nuclei, the nuclear-cytoplasmic ratio in these cells, and the relative volume of damaged endotheliocytes were determined on micropreparations of the prostate gland. Quantitative values were processed statistically.
Results and Discussion. Postresection portal hypertension in laboratory sexually mature white male rats leads to pronounced remodeling of the arterial bed of the prostate gland, which is characterized by thickening of the arterial wall, narrowing of their lumen, significant changes in Vogenvoort and Kernogan indices, atrophic, dystrophic and necrobiotic changes in endotheliocytes, a violation of their structural cellular homeostasis, endothelial dysfunction, hypoxia, dystrophic, necrotic changes in cells and stromal structures, infiltration and sclerosis. The degree of structural remodeling dominates in small-caliber arteries and when postresection portal hypertension is combined with multiple organ failure.
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