Evaluation of the coagulation system in patients with thrombotic complications under oncopathology

Authors

  • P. Ya. Bodnar I. Horbachevsky Ternopil National Medical University
  • I. M. Klishch I. Horbachevsky Ternopil National Medical University
  • A. D. Bedeniuk I. Horbachevsky Ternopil National Medical University
  • Ya. Ya. Bodnar I. Horbachevsky Ternopil National Medical University
  • T. V. Bodnar I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2022.1.12915

Keywords:

coagulation system, venous thrombosis, cervical tumors

Abstract

The aim of the work: to study the changes in blood hemostasis in patients with cervical tumors.

Materials and Methods. We examined 24 women who were divided into control group (I) – 9 patients with morphologically verified cervical tumors and group II – 15 patients who, along with morphologically verified cervical tumors diagnosed with thrombotic complications to study the indicators of hemostasis, who were being treated at Ternopil University Hospital.

Results and Discussion. The results of the study indicate that in group I of patients there were critical levels of hemostasis, which indicates the activation of the coagulation system. When comparing groups of patients in group II, a decrease in thrombin time (p <0.01), activated partial thromboplastin time (p <0.005) and prothrombin time (p <0.005) was statistically significant, indicating hypercoagulation. In the analysis of fibrinogen A and prothrombin index there was a statistical increase (p <0.01), which indicates a tendency to thrombosis with a risk of thromboembolic complications. Increased levels of level of soluble fibrin-monomer complexes (p <0.01), explain the activation of the blood coagulation system, as the latter are markers of thrombinemia in intravascular coagulation. D-dimer levels in patients with thrombosis are significantly higher than in patients without thrombosis

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Published

2022-05-20

How to Cite

Bodnar, P. Y., Klishch, I. M., Bedeniuk, A. D., Bodnar, Y. Y., & Bodnar, T. V. (2022). Evaluation of the coagulation system in patients with thrombotic complications under oncopathology. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1), 32–35. https://doi.org/10.11603/2414-4533.2022.1.12915

Issue

No. 1 (2022)

Section

ORIGINAL INVESTIGATIONS

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