Characteristics of donors with an established diagnosis of brain death in kyiv regional clinical hospital for 2021

Authors

  • M. S. Zahriichuk Kyiv Regional Clinical Hospital
  • O. Ye. Kanikovskyi M. Pyrohov Vinnytsia National Medical University
  • О. О. Pidopryhora Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine, Kyiv

DOI:

https://doi.org/10.11603/2414-4533.2022.1.12827

Keywords:

organ donation, explantation, brain death, organ transplantation

Abstract

The aim of the work: to determine the dependence of the number of organ explantations in effective post-mortem donors on age and laboratory results.

Materials and Methods. The study included 14 post-mortem donors who underwent organ explantation between May 2021 and December 2021, of whom 56.3 % were men and 43.7 % – women. By age, the patients were divided into 3 groups: group 1 – all donors; group 2 – under 50 years old, group 3 – over 50 years old.

Results and Discussion. According to the results of statistical data processing, it can be argued that the groups did not differ significantly in such laboratory parameters as the average level of creatinine, urea, sodium, ALT and AST, while at the same time there was a difference in the number of explantations for a particular organ.

Posthumous donation saves the life of at least 4 people at the same time. In Ukraine, the criteria for marginal donation are not spelled out and the criteria for donation are expanded. The age of the post-mortem donor is not a critical criterion for organ donation. The expansion of donor criteria partly covers the organ deficit. Follow-up studies in a larger group of patients are needed to further explore the effectiveness of donor use and post-transplant long-term outcomes.

References

Heldal, K., Hartmann, A., Leivestad, T., Lien, B., Foss, A.E., & Midtvedt, K. (2011). Renal transplantation is also an option for patients over 70. Tidsskr Nor Laegeforen, 131 (20), 2004-2007. DOI: 10.4045/tidsskr.10.1391. PMID: 22016126.

Yilmaz, G., Ozdemir, E., Yildar, M., Karayagiz, H., Berber, I., & Cakir, U. (2022). Graft and patient survival in kidney transplant recipients over the age of sıxty-five. Cureus, 14 (1), e20913. DOI: 10.7759/cureus.20913. PMID: 35154914; PMCID: PMC8815706.

Ruggenenti, P., Cravedi, P., Gotti, E., Plati, A., Marasà, M., Sandrini, S., Bossini, N., et al. (2021). Mycophenolate mofetil versus azathioprine in kidney transplant recipients on steroid-free, low-dose cyclosporine immunosuppression (ATHENA): A pragmatic randomized trial. PLoS Med., 24; 18(6), e1003668. DOI: 10.1371/journal.pmed.1003668. PMID: 34166370; PMCID: PMC8224852.

Vathsala, A., & Woo, K.T. (1999). Renal transplantation in cyclosporine-treated recipients at the Singapore General Hospital. Clin. Transpl., 189-197. PMID: 11038637.

Ong, S.C., & Gaston, R.S. (2021). Thirty years of tacrolimus in clinical practice. Transplantation, 105 (3), 484-495. DOI: 10.1097/TP.0000000000003350. PMID: 32541562.

Stephan, A. (2017). Organ shortage: Can we decrease the demand? Experimental and clinical transplantation. Official Journal of the Middle East Society for Organ Transplantation, Suppl. 1, 6-9. DOI: 10.6002/ect.mesot2016.l27. PMID: 28260423.

Levitt, M. (2015). Could the organ shortage ever be met? Life Sci Soc Policy, 11, 6. https://doi.org/10.1186/s40504-015-0023-1

Saidi, R.F., Hejazii Kenari, S.K. (2014). Challenges of organ shortage for transplantation: solutions and opportunities. Int. J. Organ Transplant. Med., 5 (3), 87-96. PMID: 25184029; PMCID: PMC4149736.

Maria Messina, Davide Diena, Sergio Dellepiane, Gabriella Guzzo, Luca Lo Sardo, Fabrizio Fop, Giuseppe P. Segoloni, et al. (2017). Long-term outcomes and discard rate of kidneys by decade of extended criteria donor age. CJASN, 12 (2) 323-331; DOI: 10.2215/CJN.06550616.

Bozkurt, B., Kılıç, M. (2015). Marginal donors in renal transplantation, transplantation proceedings. 47, (5), 1273-1281, ISSN 0041-1345, https://doi.org/10.1016/j.transproceed.2015.04.006.

Bae, S., Massie, A.B., Thomas, A.G., Bahn, G., Luo, X., Jackson, K.R., … Garonzik Wang, J.M. (2018). Who can tolerate a marginal kidney? Predicting survival after deceased donor kidney transplant by donor-recipient combination. American Journal of Transplantation. DOI:10.1111/ajt.14978

Published

2022-05-20

How to Cite

Zahriichuk, M. S., Kanikovskyi, O. Y., & Pidopryhora О. О. (2022). Characteristics of donors with an established diagnosis of brain death in kyiv regional clinical hospital for 2021. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1), 5–11. https://doi.org/10.11603/2414-4533.2022.1.12827

Issue

Section

ORIGINAL INVESTIGATIONS