Polymorphism of exophytic forms of papillomavirus infection in patients with genital warts of the anogenital area
DOI:
https://doi.org/10.11603/2414-4533.2021.4.12719Keywords:
human papillomavirus, genital warts, coilocytesAbstract
The aim of the work: to determine the pathomorphological features and clinical forms of papillomavirus infection in patients with genital warts of the anogenital area.
Materials and Methods. 105 patients with genital warts of the anogenital area were examined and provided with surgical care: 63 (60 %) women and 42 (40 %) men. Condyloma excision was performed by electrocoagulation using the BOWA device (Germany) with mandatory histological verification of the removed tissues. For the first time 67 (63.81 %) patients consulted a doctor. Among 38 (36.19 %) patients with relapses, 26 (68.42 %) had previously undergone destructive therapy, 12 (31.58 %) – antiviral and destructive.
Research and Discussion. Among the examined patients, single warts were diagnosed in 36 (34.29 %), multiple – 66 (62.86 %), Bushke-Levenstein warts – 3 (2.86 %). In 77 (73.33 %) patients there was a combination of acute condyloma of the anogenital area with other vegetative forms of human papilloma virus, which were located in the anogenital and other parts of the body, indicating infection with several types of human papilloma virus. The level of association of human papilloma virus, bacterial and fungal contamination was 62 (59.05 %) cases and contributed to the implementation of an alternative inflammatory process, which increases the likelihood of complications during the postoperative period. Histological examination revealed coilocytes – large light (almost white) balloon-like cells that are reservoirs of human papilloma virus, hyperkeratosis, dyskaryosis and hyperchromatosis of the nuclei.
References
Bondarenko, H.M., & Shcherbakova, Yu.V. (2014). Zastosuvannia mistsevykh zasobiv terapii v likuvanni hostrokintsevykh kondylom (ohliad) [The use of local therapies in the treatment of genital warts (review)]. Dermatolohiia ta venerolohiia. Fakhovyi zhurnal – Dermatology and Venereology. Scientific-Practical Professional Journal, 4, 5-18 [in Ukrainian].
Heriak, S.M. (2011). Papilomavirusna infektsiia yak khvoroba ХХІ stolittia: suchasni pidkhody do vedennia patsiientiv [Human papillomavirus infection: as a disease of the XXI century: modern approaches to patient management]. Medychni aspekty zdorovia zhinky – Medical Aspects of Woman’s Health, 7-2 (48), 58-61 [in Ukrainian].
Nykolov, V.V., Kovalchuk, M.T., Maryna, S. S., Pokryshko, E. V., & Pokryshko, A. O. (2015). Sposob lechenyia ostrokonechnykh kondylom u muzhchyn [Method for the treatment of genital warts in men]. Medytsynskye aspekty zdorovya muzhchiny – Medical Aspects of Men’s Health, 1 (16), 26-30 [in Ukrainian].
Stepanenko, R.L. (2010). Diagnosis and complex therapy of genital papillomavirus infection taking into account the persistence of pathogens, features of pathogenesis, clinical manifestations and course of the disease. Extended abstract of Candidate’s thesis. (Skin and venereal diseases). O. Bohomolets National Medical University, Kyiv [in Ukrainian].
Chernikova, L.I. (2016). Papilomavirusna infektsiia v praktytsi dermatoveneroloha. Ohliad literatury [Human papillomavirus infection in the practice of dermatovenereology. Systematic review]. Proceedings of the Conference (with international participation) dedicated to the 185th anniversary of Professor O.Yu. Bruyev ”Current issues of dermatology, venereology and HIV/AIDS infection. Kharkiv, June 18-19 (pp. 123-133). Kharkiv: Vodnyi spektr [in Ukrainian].
Aşkın Ö. (2017). Anogenital HPV, fundamentals of sexually transmitted infections. Retrieved from: DOI: 10.5772/intechopen.70017.
Doorbar, J., Egawa, N., Griffin, H., Kranjec, C., & Murakami, I. (2015). Human papillomavirus molecular biology and disease association. Rev. Med. Virol., 25, 2-23. DOI: 10.1002/rmv.1822.
Husseinzadeh, N. Basic therapeutic principles and the strategy in the management of the external anogenital warts (condylomas): A review. Journal of Clinical Gynecology and Obstetrics, 2, 1, 1-9. DOI: https://doi.org/10.4021/jcgo86e
Nunes, E.M, Talpe-Nunes, V., & Sichero, L. (2018). Epidemiology and biology of cutaneous human papillomavirus. Clinics (Sao Paulo). 73 (l). DOI: https://doi.org/10.6061/clinics/2018/e489s
Van Dyne E.A., Henley, S.J., Saraiya, M., Thomas, C.C., Markowitz, L.E., & Benard, V.B. (2018). Trends in human papillomavirus-associated cancers – United States, 1999-2015. MMWR Morb. Mortal Wkly Rep., 67 (33), 918-924. DOI: http://dx.doi.org/10.15585/mmwr.mm6733a2.
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