Surgical correction of adipokine and grelin level in rats with metabolic Syndrome
DOI:
https://doi.org/10.11603/2414-4533.2021.4.12713Keywords:
bariatric interventions, ghrelin, leptin, adiponectin, metabolic syndromeAbstract
The aim of the work: to investigate the level of adipokines and ghrelin in the body of experimental animals with simulated metabolic syndrome after surgical correction of different types of bariatric interventions.
Materials and Methods. The study was performed on 40 white male Wistar rats weighing 200–250 g (aged 9–10 weeks), which were kept in standard vivarium conditions. The main group of rats (n = 56) were fed a high-fat diet (over 60 % energy from fats) for 16 weeks. After that, they were divided into groups according to the type of surgical intervention: sleeve gastrectomy, Roux-en-Y gastric bypass, ligation of the left gastric artery. In the postoperative period (14 days and 1 place) the concentration of adiponectin, leptin and ghrelin were assessed.
Results and Discussion. Surgical treatment of obesity reduces ghrelin and leptin levels and increases adiponectin levels in all study groups of animals with simulated metabolic syndrome. However, in the group of rats that underwent ligation of the left gastric artery normalization of adipokines (leptin and adiponectin) and ghrelin were the best and statistically significant for metabolic syndrome group, both at day 14 and after 1 month after surgery on all comparative indicators (p <0.05).
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