Analysis of the state of lipoperoxidation processes depending on the formation of postnecrotic cyst of the pancreas

Authors

  • V. V. Boyko V. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine Kharkiv National Medical University
  • V. M. Lykhman V. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine Kharkiv Medical Academy of Postgraduate Education
  • S. V. Tkach V. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine
  • O. M. Shevchenko Kharkiv National Medical University
  • D. О. Miroshnichenko Kharkiv National Medical University
  • A. О. Merkulov V. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine
  • K. M. Yatsko V. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine
  • E. О. Beloded Kharkiv National Medical University
  • N. V. Batsman Kharkiv National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2021.4.12617

Keywords:

pancreatic necrosis, pancreatic pseudocyst, lipid peroxidation

Abstract

The aim of the work: to investigate the content of pancreatic pseudocysts with further determination of the state of free radical processes in it.

Materials and Methods. The data of the analysis of examination of 62 patients with pancreatic pseudocysts are presented. The prooxidant-antioxidant balance in the blood and in the content of pancreatic pseudocysts was studied, depending on the degree of formation of the cystic wall.

Results and Discussion. The study of the content of pancreatic pseudocysts made it possible to determine the state of free radical processes in it and revealed a high toxicity of exudate in unformed pseudocysts. The marker of the imperfection of the pseudocyst wall is the increased content of malondialdehyde in the erythrocytes of the patientsʼ blood.

References

Smeets, X., Bouhouch, N., Buxbaum, J., Zhang, H., Cho, J., Verdonk, R.C., …, & van Geenen, E. (2019). The revised Atlanta criteria more accurately reflect severity of post-ERCP pancreatitis compared to the consensus criteria. United European Gastroenterol. J., 7 (4), 557-564. DOI: 10.1177/2050640619834839.

Krivoruchko, I.A. (2013). Differentsirovannyiy podhod k vyiboru metoda lecheniya psevdokist podzheludochnoy zhelezy [Differentiated approach to the choice of treatment for pancrea­tic pseudocysts]. Klinichna khirurhiia – Clin. Surg., 7, 16-19 [in Ukrainian].

Machicado, J.D., Chari, S.T., Timmons, L., Tang, G., & Yadav, D. (2018). A population-based evaluation of the natural history of chronic pancreatitis. Pancreatology, 18 (1), 39-45. DOI: 10.1016/j.pan.2017.11.012.

Greenberg, J.A., Hsu, J., Bawazeer, M., Marshall, J., Friedrich, J.O., Nathens, A., …, & McLeod, R.S. (2016). Clinical practice guideline: management of acute pancreatitis. Can. J. Surg., 59 (2), 128-140. DOI: 10.1503/cjs.015015.

Adams, D.B. (2017). Pancreatitis: medical and surgical mana­gement. Chichester: Wiley Blackwell. 326 p.

Deng, L.H., Hu, C., Cai, W.H., Chen, W.W., Zhang, X.X., Shi, N., …, & Xia, Q. (2017). Plasma cytokines can help to identify the development of severe acute pancreatitis on admission. Medicine (Baltimore), 96 (28), e7312. DOI: 10.1097/MD.0000000000007312.

Krylova, O., Gubergrits, N., Rudenko, A., Haydar, Y., Karachynova, V. (2019). Role of NO synthases deficiency in the development of pancreatitis (experimental study). Pancreatology, 19 (1), S25-S26. DOI: 10.1016/j.pan.2019.05.059.

Downloads

Published

2022-02-18

How to Cite

Boyko, V. V., Lykhman, V. M., Tkach, S. V., Shevchenko, O. M., Miroshnichenko D. О., Merkulov A. О., … Batsman, N. V. (2022). Analysis of the state of lipoperoxidation processes depending on the formation of postnecrotic cyst of the pancreas. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (4), 5–9. https://doi.org/10.11603/2414-4533.2021.4.12617

Issue

No. 4 (2021)

Section

ORIGINAL INVESTIGATIONS

License

Copyright (c) 2022 Hospital Surgery. Journal named by L.Ya. Kovalchuk

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish their work in Hospital Surgery. Journal by L. Ya. Kovalchuk agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).