Osmotically volumetric urine index in the detection and diagnosis of the severity of central diabetes insipidus in neurosurgical patients

Authors

  • Y. V. Gnativ I. Horbachevsky Ternopil National Medical University
  • M. M. I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2021.3.12548

Keywords:

central diabetes insipidus, urine density, diuresis rate, homeostasis, urine index

Abstract

The aim of the work: to study the changes of osmotically volumetric urine index (OVUI) in patients with central diabetes insipidus and to establish its digital values at the different severity degree of the pathology.

Materials and Methods. Medical records of 52 neurosurgical patients with craniocerebral trauma (24), brain tumor operation (14) and stroke (14) s were retrospectively examined and the course of their disease was complicated by central diabetes insipidus of different severity. The comparison group consisted of 20 neurosurgical patients who had no diabetes insipidus. We developed an informative criterion of diabetes insipidus diagnosis and its severity: OVUI behind the indices of diuresis rate and urine density.

Results and Discussion. Normal hourly diuresis is 0.8–1.0 ml∙kg-1 of urine. Its density is 1012–1025. Having measured diuresis rate and urine density in 20 patients of the comparison group, we calculated it according to the above formula and found its average values: 8.0–12.0. In central diabetes insipidus the OVUI drops sharply ˂1.0. We found that in mild diabetes insipidus, the OVUI is 0.66–0.41, moderate – 0.4–0.21, and severe – ˂0.2–0.05. An indicator of the adequacy of intensive therapy for diabetes insipidus is the increase of OVUI to normal. For early diagnosis of central diabetes insipidus in neurosurgical patients, it is advisable to conduct a simultaneous study the rate of diuresis and urine density, which are used to calculate the OVUI according to the proposed formula. Normally, the OVUI is in the range of 8.0–12.0. In central diabetes insipidus, the OVUI decreases to 0.6–0.41, moderate – to 0.4–0.21, and severe – to 0.2–0.05. A sign of the effectiveness of intensive care in patients with diabetes insipidus is an increase in the OVUI ˃1.0 in each of the experimental portions of urine.

References

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Published

2021-12-03

How to Cite

Gnativ, Y. V., & M. M. (2021). Osmotically volumetric urine index in the detection and diagnosis of the severity of central diabetes insipidus in neurosurgical patients. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (3), 106–110. https://doi.org/10.11603/2414-4533.2021.3.12548

Issue

No. 3 (2021)

Section

EXPERIENCE OF WORK

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