The features of the cytokine profile and immune status in patients with Condylomas of the anogenital unit

Authors

  • A. M. Slepichko Luhansk State Medical University
  • I. M. Deykalo I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2021.3.12539

Keywords:

human papillomavirus, acute condylomas, cytokine profile, immune status

Abstract

The aim of the work: to study changes in cellular and humoral immunity in patients with acute condylomas (AC) of the anogenital unit and determine the degree of disorders; to investigate the state of the cytokine profile as predictors of the course of the postoperative period and treatment effectiveness.

Materials and Methods. 105 patients with AC of the anogenital unit were examined: 63 (60 %) women and 42 (40 %) men. The state of cellular and humoral immunity, the level of cytokines TNFa, IL-4, IL-6, IL-8 were determined.

Results and Discussion. The frequency of chronic somatic pathology was 96 (91.43 %). It was identified a significant decrease in the absolute and relative number of lymphocytes and its T-population. Against the background of lymphopenia, an increase in the level of B-lymphocytes (CD22) was revealed in the absolute and relative amount and concentration of Ig A and Ig G that indicates the presence of a chronic inflammatory process and/or inflammation of viral etiology with depletion of the T-link of immunity. The level of IL-4 was 2.4 higher than in the control group and was equal to (4.14±0.24) pg/ml; IL-6 – 2.7 – (3.77±0.45) pg/ml; IL-8 – 1.9 – (29.82±3.15) pg/ml; TNFa – 3.0 – (7.64±0.93) pg/ml. It was assessed the dependence level of TNFa, IL-6, IL-4 and IL-8 in the links of cellular and humoral immunity characterized by depletion of the cellular link-general lymphopenia, T-lymphopenia with a decrease in its absolute and relative values in all populations, an increase in the level of B-lymphocytes, IG G and IG A. The increasing levels of cytokines IL4, IL-6, IL-8 and TNFa in patients reflect the degree of distribution of AC and corresponds to the natural of concominant perifocal inflammation that should be used as a factor in predicting the course of the postoperative period and the effectiveness of treatment.

References

Bondarenko, H.M., & Shcherbakova, Yu.V. (2014). Zastosuvannia mistsevykh zasobiv terapii v likuvanni hostrokintsevykh kondylom (ohliad) [The use of local therapy in the treatment of genital warts (review)]. Dermatolohiia ta venerolohiia. Fakhovyi zhurnal – Dermatology and Venereology. Scientific-practical Professional Journal, 4, 5-18 [in Ukrainian].

Heriak, S.M. (2011). Papilomavirusna infektsiia yak khvoroba XXI stolittia: suchasni pidkhody do vedennia patsiientiv [Human papillomavirus infection: as a disease of the XXI century: Modern approaches to patient management]. Medychni aspekty zdorovia zhinky – Medical Aspects of Woman’s Health, 7-2 (48), 58-61 [in Ukrainian].

Dziublyk, I.V., & Kovaliuk, O.V. (2012). Papilomavirusna infektsiia: pohliad na problemu likaria-virusoloha [Human papillomavirus infection: perspective of virologist]. Ukrainskyi khimioterapevtychnyi zhurnal – Ukrainian Chemotherapeutic Journal, 1-2 (25), 98-106 [in Ukrainian].

Kamynskyi, V.V., Shalko, M.N., Vorobeva, L.Y., Romashchenko, O.V., Hrynevych, A.Y. (2015). Proteflazyd®: spetsyfycheskaya aktyvnost v doklinicheskykh issledovaniyakh, effektivnost i bezopasnost primeneniya v klinicheskoy praktike pry zabolevaniyakh, vyzvannykh virusom papyllomy cheloveka (systematycheskyy obzor) [Proteflazid®: efficacy and safety in clinical practice for diseases caused by human papillomavirus (systematic review)]. Zdorovye zhenshchiny – Health of a Woman, 3, 128- 138 [in Ukrainian].

Calculation of variation series indicators. Retrieved from: https://medstatistic.ru/calculators/calcvaries.htm

Stepanenko, R.L. (2010). Diagnosis and complex therapy of genital papillomavirus infection taking into account the persistence of pathogens, features of pathogenesis, clinical manifestations and course of the disease. Candidate’s Extended abstract. O. Bohomolets National Medical University, Kyiv [in Ukrainian].

Chernikova, L.I. (2016). Papilomavirusna infektsiia v praktytsi dermatoveneroloha. Ohliad literatury [Human papillomavirus infection in the practice of dermatovenereology. Systematic review]. Proceedings of the Conference (with international participation) dedicated to the 185th anniversary of Professor O.Yu. Bruyev ”Current issues of dermatology, venereology and HIV/AIDS infection”. Kharkiv, June 18 – 19. 2016 (pp. 123-133). Kharkiv: Vodnyi spektr [in Ukrainian].

Frolov, V.M., Haidash, Y.S., Peresadyn, N.A. (1989). Monoklonalnye antytela v izuchenii pokazateley kletochnogo immuniteta u bolnykh [Monoclonal antibodies in the study of cellular immunity in patients]. Laboratornoye delo – Laboratory Business, 6, 71-72 [in Russian].

Harper, D.M., Franco E.L., Wheeler C, Ferris D.G., Jenkins D.., Schuind A., Zahaf T., et al (2004). Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet, 364, 1757-1765. DOI: 10.1016 / S0140-6736 (04) 17398-4.

Nunes, E.M., Talpe-Nunes, V., & Sichero, L. (2018). Epidemiology and biology of cutaneous human papillomavirus. Cli­nics (Sao Paulo), 73 (suppl 1). DOI:https://doi.org/10.6061/cli­nics/2018/e489s

Silins, I., Kallings, L., & Dillner, J. (2000). Correlates of the spread of human papillomavirus infection. Biomarkers Prev., 9, 953-959. DOI: Published September 2000.

Van Dyne E.A., Henley, S.J., Saraiya, M., Thomas, C.C., Markowitz, L.E., & Benard, V.B. (2018). Trends in human papillomavirus-associated cancers – United States, 1999-2015. MMWR Morb Mortal Wkly Rep., 67 (33), 918-924. DOI: http://dx.doi.org/10.15585/mmwr.mm6733a2

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Published

2021-12-03

How to Cite

Slepichko, A. M., & Deykalo, I. M. (2021). The features of the cytokine profile and immune status in patients with Condylomas of the anogenital unit. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (3), 45–49. https://doi.org/10.11603/2414-4533.2021.3.12539

Issue

No. 3 (2021)

Section

EXPERIENCE OF WORK

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