Surgery for biliary stricture in chronic pancreatitis

Authors

  • V. G. Yareshko Zaporizhia Medical Academy of Post-Graduate Education
  • Yu. O. Mikheiev Zaporizhia Medical Academy of Post-Graduate Education
  • V. D. Skrypko Zaporizhia Medical Academy of Post-Graduate Education
  • O. F. Shpylenko Zaporizhia Medical Academy of Post-Graduate Education

DOI:

https://doi.org/10.11603/2414-4533.2021.4.12479

Keywords:

chronic pancreatitis, steatorrhea, biliary stricture, biliary hypertension, mechanical jaundice

Abstract

The aim of the work: to determine the optimal timing of surgery to prevent biliary stricture (BS) in chronic pancreatitis (CP), the optimal type of intervention in the bile ducts, the optimal combination of surgery on the bile ducts and pancreas and to establish indications for the latter.

Materials and Methods. Retrospective analysis of case histories of patients who were operated due to chronic pancreatitis from 2001 to 2020. Diagnostic criteria of BS were mechanical jaundice and/or dilatation of of the hepatic choledochus ≥10 mm. BS was confirmed by intraoperative cholangiography. Choledochoduodenostomy, hepatic and choledochoenterostomy, transduodenal papillosphincterotomy, duodenum-preserving resections of the pancreatic head were performed. The effectiveness of operations assessed by the absence of cholangitis/mechanical jaundice during observation. Statistical analysis was performed using IBM SPSS Version27. Pearsonʼs χ², Fisherʼs exact criterion was used to analyze categorical data. The level of statistical significance is set at p<0.05.

Results and Discussion. No recurrence of BS achieved in 85.7 % of patients. Recurrence of BS (cholangitis/jaundice) was observed in 8 patients (14.3 %). Signs of recurrence were found: in the group of   transduodenal papillosphincterotomy in 33.3 %, in 16.7 % of patients with сholedochoduodenostomy, in 9.7 % of patients with duodenum-preserving resections of the pancreatic head . For the latter, resection decompression was supplemented in these patients by fenestration of the choledochus into the resection cavity. BS was observed in 18.8 % of patients with symptoms lasting up to 3 years and in 33.8 % – more than 3 years.

References

Ma, M.X., Jayasekeran, V., & Chong, A.K. (2019). Benign biliary strictures: Prevalence, impact, and management strategies. Clin. Exp. Gastroenterol., 12, 83-92. DOI: 10.2147/CEG.S165016.

Saxena, P., Diehl, D.L., Kumbhari, V., Shieh, F., Buscaglia, J.M., Sze, W., …, & Khashab, M.A. (2015). A us multicenter study of safety and efficacy of fully covered self-expandable metallic stents in benign extrahepatic biliary strictures. Dig. Dis. Sci., 60 (11), 3442-3448. DOI: 10.1007/s10620-015-3653-5.

Seicean, A., & Vultur, S. (2015). Endoscopic therapy in chronic pancreatitis: current perspectives. Clin. Exp. Gastroen­terol., 8, 1-11. DOI: 10.2147/CEG.S43096.

Nakai, Y., Isayama, H., Wang, H.P., Rerknimitr, R., Khor, C., Yasuda, I., ..., & Devereaux, B. (2020). International consensus statements for endoscopic management of distal biliary stricture. J. Gastroenterol. Hepatol., 35 (6), 967-979. DOI: 10.1111/jgh.14955.

Leong, R.W. (2015). Metallic stents for Benign extrahepatic biliary stricture: in praise of self-expansion? Dig. Dis. Sci., 60 (11), 3158-3159. DOI: 10.1007/s10620-015-3705-x.

Ohyama, H., Mikata, R., Ishihara, T., Sakai, Y., Sugiyama, H., Yasui, S., & Tsuyuguchi, T. (2017). Efficacy of multiple biliary stenting for refractory benign biliary strictures due to chronic calcifying pancreatitis. World J. Gastrointest. Endosc., 9 (1), 12-18. DOI: 10.4253/wjge.v9.i1.12.

Bartel, M.J., Higa, J.T., & Tokar, J.L. (2019). The status of sems versus plastic stents for benign biliary strictures. Curr. Gastroenterol. Rep., 21 (7), 29 DOI: 10.1007/s11894-019-0696-3.

Shetty, A.J., Pai, C.G., Shetty, S., & Balaraju, G. (2015). Pancreatic calculus causing biliary obstruction: Endoscopic therapy for a rare initial presentation of chronic pancreatitis. Dig. Dis. Sci., 60 (9), 2840-2843. DOI: 10.1007/s10620-015-3670-4.

Haapamäki, C., Kylänpää, L., Udd, M., Lindström, O., Grönroos, J., Saarela, A., …, & Halttunen, J. (2015). Randomized multicenter study of multiple plastic stents vs. covered self-expandable metallic stent in the treatment of biliary stricture in chronic pancreatitis. Endoscopy, 47 (7), 605-610. DOI: 10.1055/s-0034-1391331.

Perri, V., Boškoski, I., Tringali, A., Familiari, P., Mutignani, M., Marmo, R., & Costamagna, G. (2012). Fully covered Self-expandable metal stents in biliary strictures caused by chro­nic pancreatitis not responding to plastic stenting: a prospective study with 2 years of follow-up. Gastrointest. Endosc., 75 (6), 1271-1277. DOI: 10.1016/j.gie.2012.02.002.

Kitano, M., Gress, T.M., Garg, P.K., Itoi, T., Irisawa, A., Isayama, H., …, & Whitcomb, D.C. (2020). International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association OF Pancreatology, the American pancreatic Association, the Japan Pancreas society, and European pancreatic club. Pancreatology, 20 (6), 1045-1055. DOI: 10.1016/j.pan.2020.05.022.

Udd, M., Kylänpää, L., & Kokkola, A. (2020). The role of endoscopic and surgical treatment in chronic pancreatitis. Scand. J. Surg., 109 (1), 69-78. DOI: 10.1177/1457496920910009.

Huszár, O., Kokas, B., Mátrai, P., Hegyi, P., Pétervári, E., Vincze, Á., ..., & Szücs, Á. (2017). Meta-analysis of the long term success rate of different interventions in benign biliary strictures. PloS One, 12 (1), e0169618.

Issa, Y., Kempeneers, M.A., Bruno, M.J., Fockens, P., Poley, J.W., Ahmed Ali, U., ..., & Boermeester, M.A. (2020). Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis. JAMA, 323 (3), 237-247. DOI: 10.1001/jama.2019.20967.

Yang, C.J., Bliss, L.A., Freedman, S.D., Sheth, S., Vollmer, C.M., Ng, S.C., …, & Tseng, J.F. (2015). Surgery for chronic pancreatitis. Pancreas, 44 (5), 819-823. DOI: 10.1097/MPA.0000000000000333.

Bouwense, S.A.W., Kempeneers, M.A., van Santvoort, H.C., Boermeester, M.A., van Goor, H., & Besselink, M.G. (2019). Surgery in chronic pancreatitis: indication, timing and procedures. Visc. Med., 35 (2), 110-118. DOI: 10.1159/000499612.

Cauchy, F., Regimbeau, J.M., Fuks, D., Balladur, P., Tiret, E., & Paye, F. (2014). Influence of bile duct obstruction on the results of Freyʼs procedure for chronic pancreatitis. Pancreatology, 14 (1), 21-26. DOI: 10.1016/j.pan.2013.10.008.

Hyun, J.J., Irani, S.S., Ross, A.S., Larsen, M.C., Gluck, M., & Kozarek, R.A. (2021). Incidence and significance of biliary stricture in chronic pancreatitis patients undergoing extracorporeal shock wave lithotripsy for obstructing pancreatic duct stones. Gut. Liver, 15 (1), 128-134. DOI: 10.5009/gnl19380.

Kleeff, J., Neoptolemos, J.P., Muñoz, J., Akisik, F., Rebours, V., Drewes, A.M., ..., & Neoptolemos, J.P. (2017). Chronic pancreatitis. Nat. Rev. Dis. Primers., 3 (1), 17060. DOI: 10.1038/nrdp.2017.60.

Smith, I., Monkemuller, K., & Wilcox, C.M. (2015). Incidentally identified common bile duct dilatation. J. Clin. Gastroenterol., 49 (10), 810-815. DOI: 10.1097/MCG.0000000000000394.

De Angelis, C., Marietti, M., Bruno, M., Pellicano, R., & Rizzetto, M. (2015). Endoscopic ultrasound in common bile duct dilatation with normal liver enzymes. World J. Gastrointest. Endosc., 7 (8), 799-805. DOI: 10.4253/wjge.v7.i8.799.

Ray, S., Ghatak, S., Das, K., Dasgupta, J., Ray, S., Kham­rui, S., ..., & Das, S. (2015). Surgical management of benign biliary stricture in chronic pancreatitis: a single-center experience. Indian J. Surg., 77 (S2), 608-613. DOI: 10.1007/s12262-013-0940-2.

Ray, S., Das, K., Jana, K., Das, R., Kumar, D., & Khamrui, S. (2020). Frey procedure combined with biliary diversion for the treatment of chronic pancreatitis-related biliary obstruction: Impact of the types of diversion. World J. Surg., 44 (7), 2359-2366. DOI: 10.1007/s00268-020-05465-7.

Merdrignac, A., Bergeat, D., Rayar, M., Harnoy, Y., Tur­ner, K., Courtin-Tanguy, L., …, & Sulpice, L. (2016). Frey procedure combined with biliary diversion in chronic pancreatitis. Surgery, 160 (5), 1264-1270. DOI: 10.1016/j.surg.2016.05.006.

Leppard, W.M., Shary, T.M., Adams, D.B., & Morgan, K.A. (2011). Choledochoduodenostomy: Is it really so bad? J. Gastrointest. Surg., 15 (5), 754-757. DOI: 10.1007/s11605-011-1465-2.

Tocchi, A., Mazzoni, G., Liotta, G., Lepre, L., Cassini, D., & Miccini, M. (2001). Late development of bile duct cancer in patients who had Biliary-Enteric drainage for benign disease: A follow-up study of more than 1,000 patients. Ann. Surg., 234 (2), 210-214. DOI: 10.1097/00000658-200108000-00011.

Ke, N., Jia, D., Huang, W., Nunes, Q.M., Windsor, J.A., Liu, X., & Sutton, R. (2018). Earlier surgery improves outcomes from painful chronic pancreatitis. Medicine, 97 (19). DOI: 10.1097/MD.0000000000010651.

Published

2022-02-18

How to Cite

Yareshko, V. G., Mikheiev, Y. O., Skrypko, V. D., & Shpylenko, O. F. (2022). Surgery for biliary stricture in chronic pancreatitis. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (4), 65–71. https://doi.org/10.11603/2414-4533.2021.4.12479

Issue

Section

EXPERIENCE OF WORK