Features of compensatory processes of the duodenum in obturative cholestasus in combination with decompression of the biliary pathways and enterosorption

Authors

  • S. O. Grabchak I. Horbachevsky Ternopil National Medical University
  • A. D. Bedenyuk I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2021.1.12019

Keywords:

obstructive cholestasis, duodenum, endogenous intoxication, sorbent

Abstract

The aim of the work:  to evaluate the effectiveness of the use of enterosbent in combination with cold stochaestostomy and their impact on functional changes in the duodenum in obstructive cholestasis.

Materials and Methods. The peculiarities of the compensatory processes of the duodenum in long-term obstructive cholestasis, which was modeled by ligation of the common bile duct, were studied. Changes in biochemical parameters in the serum of pigs at 3, 7, 14 and 28 days of simulated obstructive cholestasis were analyzed.

Results and Discussion. Studies have shown that the combination of choledochoduodenostomy with enterosorption in a week after correction of 28-day mechanical jaundice significantly reduces endogenous intoxication, lipid peroxidation, increases antioxidant protection of organs and the body, improves pigment metabolism and liver function. Under these experimental conditions, catalase activity is normalized within 14 to 28 days of the start of the experiment.

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Published

2021-04-30

How to Cite

Grabchak, S. O., & Bedenyuk, A. D. (2021). Features of compensatory processes of the duodenum in obturative cholestasus in combination with decompression of the biliary pathways and enterosorption. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1), 38–43. https://doi.org/10.11603/2414-4533.2021.1.12019

Issue

No. 1 (2021)

Section

EXPERIMENTAL INVESTIGATIONS

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