Features of compensatory processes of the duodenum in obturative cholestasus in combination with decompression of the biliary pathways and enterosorption

Authors

  • S. O. Grabchak I. Horbachevsky Ternopil National Medical University
  • A. D. Bedenyuk I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2021.1.12019

Keywords:

obstructive cholestasis, duodenum, endogenous intoxication, sorbent

Abstract

The aim of the work:  to evaluate the effectiveness of the use of enterosbent in combination with cold stochaestostomy and their impact on functional changes in the duodenum in obstructive cholestasis.

Materials and Methods. The peculiarities of the compensatory processes of the duodenum in long-term obstructive cholestasis, which was modeled by ligation of the common bile duct, were studied. Changes in biochemical parameters in the serum of pigs at 3, 7, 14 and 28 days of simulated obstructive cholestasis were analyzed.

Results and Discussion. Studies have shown that the combination of choledochoduodenostomy with enterosorption in a week after correction of 28-day mechanical jaundice significantly reduces endogenous intoxication, lipid peroxidation, increases antioxidant protection of organs and the body, improves pigment metabolism and liver function. Under these experimental conditions, catalase activity is normalized within 14 to 28 days of the start of the experiment.

References

Belyayev, A.N., Belyayev, S.A., Kostin, S.V., Tyurina, N.A., & Boyarkin, Ye.V. (2018). Endogennaya intoksikatsiya pri mekhanicheskoy zheltukhe i vozmozhnosti yeye patogeneticheskoy korrektsii [Endogenous intoxication in mechanical joundice and the possibility of its pathogenetic correction]. Eksperimentalnaya i klinicheskaya gastroenterologiya – Experimental and Clinical Gastroenterology, 157 (9), 101-106. DOI: 10.31146/1682-8658-ecg157-9-101-106 [in Russian].

Pylypchuk, V.I. (2016). Varianty operatsiinykh vtruchan na zhovchovyvidnykh protokakh pry khronichnomu pankreatyti z oznakamy biliarnoi hipertenzii [Possible surgeries on bile ducts in cases of chronic pancreatitis with signs of biliary hypertension]. Shpytalna khirurhiia. Zhurnal imeni L.Ya. Kovalchuka – Hospital Surgery. Journal named by L.Ya. Kovalchuk, 2, 27-31. DOI: https://doi.org/10.11603/2414-4533.2016.2.6406 [in Ukrainian].

Sobazstiano, P., & di Molat, F. (2013). Pathophysiology of chronic damage. Acute and Chronic Pancreatitis. Turin: Editioni Minerva modica.

Patent UA78273, MPK G 09B23/28(2006/01). Sposib mode­liuvannia mekhanichnoi zhovtianytsi [A method for modeling mechanical jaundice]. M.S. Hnatiuk – No U201211327; zaiavl. 01.10.2012; оpubl.11.03.2013, Bull. No. 5 [in Ukrainian].

Vlasov, A.P., Zaitsev, P.P., Bolotskikh, V.A., Vlasova, T.I., Davydkin, V.I., Sheyranov, N.S., & Okunev, N.A. (2018). Vozmozhnosti indutsirovaniya reparatsii tkaney pri mekhanicheskoy zheltukhe neopukholevogo proiskhozhdeniya [Рossibilities of tissue repair induction during mechanical jaundice of non-tumor genesis]. Khirurgiya. Zhurnal im. N.I. Pirogova – Surgery. Journal named after N.I. Pyrogov, 12, 57-64. DOI: https://doi.org/10.17116/hirurgia201812157 [in Russian].

Bahrii, M.M., Dibrova, V.A., Popadynets, O.H., & Hrychuk, M.I. (2008). Metodyka morfolohichnykh doslidzhen [Methods of morphological studies]. Vinnytsia: Nova-Knyha [in Ukrainian].

Hnatiuk, M.S., Tatarchuk, L.V., & Hrabchak, S.O. (2016). Osoblyvosti strukturnoi perebudovy sudyn hemomikrotsyrkulyatornoho rusla dvanadtsiatypaloi kyshky pry obturatsiinomu kholestazi [Peculiarities of structural reconstruction of microhemocirculatory bed vessels of duodenum at the obturative cholestasis]. Zdobutky klinichnoi i eksperymentalnoi medytsyny – Achievements of Clinical and Experimental Medicine, 4, 36-40. DOI: https://doi.org/10.11603/1811-2471.2016.v0.i4.7073 [in Ukrainian].

Horalskyi, L.P., Harhula, T.I., & Hnatiuk, M.S. (2012). Strukturna perebudova hemomikrotsyrkuliatornoho rusla dvanadtsiatypaloi kyshky pry perebihu yii vyrazky v umovakh dii khimichnoho faktora [Structural restructuring of the hemomicrocirculatory tract of the duodenum during the course of its ulcer under conditions of chemical factor]. Zdobutky klinichnoi i eksperymentalnoi medytsyny – Achievements of Clinical and Experimental Medicine, 2 (17), 39-42 [in Ukrainian].

Dzyubanovskyi, O.I., & Hudyma, A.A. (2017). Vplyv dekompresii zhovchovyvidnykh shliakhiv na dynamiku protsesiv zhovchoutvorennia i zhovchovydilennia pislia eksperymentalnoho kholestazu riznoi tryvalosti [Impact of the biliary ducts decompression on dynamics of bile production and bile excretion after experimental cholestasis of different duration]. Kli­nichna khirurhiia – Clinical Surgery, 10, 66-69. DOI: https://doi.org/10.26779/2522-1396.2017.10.66 [in Ukrainian].

Kashaeva, M.D., Proshin, A.V., Golushko, A.V., & Gavrilova, K.V. (2020). Dinamika pokazateley gomeostaza u bol'nykh s mekhanicheskoy zheltukhoy neopukholevoy etiologii [Dynamics of indicators of homeostasis in patients with mechanical jaundy nontumorous ethiology]. Mediko-farmatsevticheskiy zhurnal “Puls” – Medical & Pharmaceutical Journal “Pulse”, 22, 2, 42-48. DOI: http://dx.doi.org/10.26787/nydha-2686-6838-2020-22-2-42-48 [in Russian].

Kravets, V.V. (2008). Morfolohichni zminy u tonkii kysh­tsi pid vplyvom riznykh endohennykh ta ekzohennykh chynnykiv (ohliad literatury) [Morphological changes in the small intestine under the influence of various endogenous and exogenous factors (literature review)]. Visnyk Sumskoho derzh. un-tu. Ser. “Medy­tsyna” – Bulletin of the Sumy State University. Ser. “Medicine”, 1, 5-16 [in Ukrainian].

Shiff, Yu.R., Sorrel, M.F., & Meddrey, U.S. (2010). Bolezni pecheni po Shiffu. Virusnyye gepatity i kholestaticheskiye zabo­levaniya: rukovodstvo [Diseases baked according to Schiff. Viral hepatitis and cholestatic diseases: a guide]. Ivashkin, V.T. (Ed.). Moscow: GEOTAR-Media [in Russian].

Yemelyanov, S.I., Briskin, B.S., Demidov, D.A., & Demidova, T.I. (2010). Vozmozhnosti yenterosorbtsii i yevolyutsiya yenterosorbentov dlya lecheniya khirurgicheskogo yendotoksikoza [Possibilities of enterosorption and evolution of enterosorbents for the treatment of surgical endotoxicosis]. Ekperim. i klinich. gastroenterologiya – Experimental and Clinical Gastroenterology, 11, 84-89 [in Russian].

Downloads

Published

2021-04-30

How to Cite

Grabchak, S. O., & Bedenyuk, A. D. (2021). Features of compensatory processes of the duodenum in obturative cholestasus in combination with decompression of the biliary pathways and enterosorption. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1), 38–43. https://doi.org/10.11603/2414-4533.2021.1.12019

Issue

No. 1 (2021)

Section

EXPERIMENTAL INVESTIGATIONS

License

Copyright (c) 2021 Hospital Surgery. Journal named by L.Ya. Kovalchuk

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish their work in Hospital Surgery. Journal by L. Ya. Kovalchuk agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  
  2. Лицензия Creative Commons
  3. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)