Clinical and pathogenetic significance of proinflammatory cytokines indicators in patients with erysipelas
DOI:
https://doi.org/10.11603/2414-4533.2021.1.12015Keywords:
erysipelas, cytokines, inflammationAbstract
The aim of the work: to determine the pathogenetic and clinical significance of proinflammatory cytokines in patients with various forms of erysipelas.
Materials and Methods. 114 case histories of patients who underwent inpatient treatment in the center of purulent-septic surgery in the Non-profit municipal enterprise “City Hospital No. 3” in Zaporizhzhia for the period 2019–2020 were analyzed retrospectively and prospectively.
According to the forms of the disease, patients were distributed as follows: erythematous – 24 (21.0 %), bullous – 28 (24.6 %), phlegmonous form – 48 (42.1 %), necrotic – 14 (12.3 %). Recurrent cases of the disease were observed in 21 patients. Among them: erythematous form – 4 (16.7 %), in bullous – 5 (17.9 %), phlegmonous – 9 (18.7 %), necrotic – 3 (21.4 %).
Results and Discussion. Regularities of dynamics of changes of proinflammatory cytokines IL-1β, IL-6 and TNF-α at various forms of erysipelas were established. The dynamics of changes in the content of cytokines in the serum of patients with erysipelas indicated the dependence of the imbalance of these indicators on the severity of the inflammatory process.
It was revealed a significant increase in IL-1β, TNF-α, IL-6 (p <0,05) in destructive forms of erysipelas in the acute period of the disease compared with erythematous, which is one of the important pathogenetic mechanisms in the development of local purulent foci of infection. In patients with primary erythematous and destructive forms, a significant (p<0.05) increase in the levels of IL-1β, TNF-α and IL-6 compared with recurrent forms was noted.
References
Bashkina, О.А., Samotrueva, М.А., Azhikova, А.К., & Pakhnova, L.R. (2019). Neyroimmunoendokrinnaya regulyatsiya fiziologicheskikh i patofiziologicheskikh protsessov v kozhe [Neuroimmunoendocrine regulation of the skin functioning]. Meditsinskaya immunologiya – Medical Immunology, 21, 807-820. DOI: 10.15789/1563-0625-2019-5-807-820 [in Russian].
Brazhnik, E.A., & Ostroushko, A.P. (2016). Rozhistoye vospaleniye v khirurgicheskoy praktike [Erysipelas in a surgical practice]. Nauchnoe obozrenie. Meditsinskie nauki – Sci. Rev. Med. Sci., 4, 14-17 [in Russian].
Gopatza, G.V., & Ermakova, L.A. (2016). Rozha: sovremennoye sostoyaniye problemy [Erysipelas: current condition of the problem]. Nauchnyy almanakh – Scientific Almanac, 1-2, 364-341. DOI: 10.17117/na.2016.01.02.364 [in Russian].
Emelyanov, A.S., Emelyanova, A.N., Pushkarev, B.S., & Vitkovskiy, Yu.A. (2018). Polimorfizm promotornogo regiona rs1800629 gena TNFα i ego vliyanie na soderzhanie faktora nekroza opukholey alfa v krovi zdorovykh lits i bolnykh rozhey [Promoter region rs1800629 TNFα polymorphism and its influence on tumor necrosis factor alpha concentration in blood of healthy individuals and patients with erysipelas]. Meditsinskaya immunologiya – Medical Immunology, 20 (3), 411-416. DOI: 10.15789/1563-0625-2018-3-411-416 [in Russian].
Ratnikova, L.I., Ship, S.A., Bespalova, M.K., & Garifanova, A.R. (2016). Komorbidnost rozhi i endokrinnykh zabolevaniy [Comorbidity of erysipelas and endocrine diseases]. Nauchnyy almanakh – Scientific Almanac, 3, 341-346. DOI: 10.17117/na.2016.05.03.341 [in Russian].
Prasad, P.A., Fang, M.C., Abe-Jones, Y., Calfee, C.S., Matthay, M.A., & Kangelaris, K.N. (2019). Time to recognition of sepsis in the emergency department using electronic health record data: a comparative analysis of systemic inflammatory response syndrome, sequential organ failure assessment, and quick sequential organ failure assessment. Crit. Care Med., 48 (2), 200-209. DOI: 10.1097/CCM.0000000000004132.
Rhodes, A., Evans, L.E., Alhazzani, W., Levy, M.M., Antonelli, M., Ferrer, R., ..., & Dellinger, R.P. (2017). Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med., 43 (3), 304-377. DOI: 10.1007/s00134-017-4683-6.
Seymour, C.W., Liu, V.X., Iwashyna, T.J., Brunkhorst, F.M., Rea, T.D., Scherag, A., …, & Angus, D.C. (2016). Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 23 (8), 762-774. DOI: 10.1001/jama.2016.0288.
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