Clinical and pathogenetic significance of proinflammatory cytokines indicators in patients with erysipelas
DOI:
https://doi.org/10.11603/2414-4533.2021.1.12015Keywords:
erysipelas, cytokines, inflammationAbstract
The aim of the work: to determine the pathogenetic and clinical significance of proinflammatory cytokines in patients with various forms of erysipelas.
Materials and Methods. 114 case histories of patients who underwent inpatient treatment in the center of purulent-septic surgery in the Non-profit municipal enterprise “City Hospital No. 3” in Zaporizhzhia for the period 2019–2020 were analyzed retrospectively and prospectively.
According to the forms of the disease, patients were distributed as follows: erythematous – 24 (21.0 %), bullous – 28 (24.6 %), phlegmonous form – 48 (42.1 %), necrotic – 14 (12.3 %). Recurrent cases of the disease were observed in 21 patients. Among them: erythematous form – 4 (16.7 %), in bullous – 5 (17.9 %), phlegmonous – 9 (18.7 %), necrotic – 3 (21.4 %).
Results and Discussion. Regularities of dynamics of changes of proinflammatory cytokines IL-1β, IL-6 and TNF-α at various forms of erysipelas were established. The dynamics of changes in the content of cytokines in the serum of patients with erysipelas indicated the dependence of the imbalance of these indicators on the severity of the inflammatory process.
It was revealed a significant increase in IL-1β, TNF-α, IL-6 (p <0,05) in destructive forms of erysipelas in the acute period of the disease compared with erythematous, which is one of the important pathogenetic mechanisms in the development of local purulent foci of infection. In patients with primary erythematous and destructive forms, a significant (p<0.05) increase in the levels of IL-1β, TNF-α and IL-6 compared with recurrent forms was noted.
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