Pathophysiological features of systemic hemodynamics and oxygen supply Of tissues in patients with obstructive sleep apnea-hypopnea syndrome during The day
DOI:
https://doi.org/10.11603/2414-4533.2020.4.11784Keywords:
obstructive sleep apnea-hypopnea syndrome, systemic hemodynamics, hypoxia, oxygen supply to tissuesAbstract
The aim of the work: to study the peculiarities of the functioning of systemic hemodynamics and oxygen supply of tissues in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) during their activity (day).
Materials and Methods. The study was conducted in 66 patients with OSAHS. The control group consisted of individuals of the same age and body weight, in whom OSAHS was not confirmed by polysomnographic examination.
Results and Discussion. A study of systemic hemodynamics and oxygen balance: features of oxygen supply disorders (degree of pulmonary hypoxia), oxygen binding by hemoglobin (degree of hemic hypoxia), the effectiveness of oxygen supply to tissues (integrated indicator of oxygen deficiency) in patients with OSAHS. It was established that during the day, synchronously with the severity of the pathology, the activity of the cardiovascular system increases: cardiac output, heart rate and total peripheral vascular resistance.
The most informative was the Robinson's index, which compared with the indicators of the control group – (104.9±1.2) – in patients with mild was (115.6±2.0), with OSAHS moderate – (125.5±1.8), and in the most severe contingent – (137.1±2.1) – which is a predictor of the development of arterial hypertension and organ disorders.
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