Postoperative prevention of chronic kidney disease in patients with renal cell Carcinoma
DOI:
https://doi.org/10.11603/2414-4533.2020.3.11465Keywords:
renal cell carcinoma, chronic kidney disease, arterial hypertensionAbstract
The aim of the work: to investigate the effect on renal function in patients with renal cell carcinoma (RCC) as ACE inhibitors (perindopril arginine) monotherapy and in combination with Ca-channel blockers in the treatment of concomitant arterial hypertension.
Materials and Methods. The study involved 38 patients with RCC. All patients were diagnosed with RCC for the first time, according to the International Classification of TNM (T1 N0 M0). Group 1 included 17 patients. In addition to the above-mentioned surgical treatment, a combination of ACE inhibitors (perindopril arginine 5 mg) and Ca-channel blockers (amlodipine 5 mg) Bi-prestrium was used to treat arterial hypertension in all patients of group I. Group 2 included 21 patients who, in contrast to group I patients, were treated with ACE inhibitors (perindopril arginine 5 mg) for the treatment of arterial hypertension.
Results and Discussion. As a result of the treatment, during 3 months of follow-up, in both groups of the study there was a statistically significant decrease in the mean values of systolic and diastolic blood pressure to normal values. As a result of the study, during 3 months of follow-up, in patients of group II of the study there was a statistically significant increase in mean values of serum creatinine and an increase in GFR compared with patients in group I.
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