The level and dynamics of indicators of cytokine profile in the treatment of patients with acute adhesive intestinal obstruction in the stage of decompensation
DOI:
https://doi.org/10.11603/2414-4533.2020.1.10748Keywords:
acute adhesive intestinal obstruction, cytokinesAbstract
The aim of the work: to study the dynamics of pro- and anti-inflammatory cytokines in patients with acute adhesive intestinal obstruction in the stage of compensation and decompensation and to evaluate the effectiveness of the developed method of complex postoperative treatment.
Materials and Methods. 182 patients with acute adhesive intestinal obstruction were examined. Of these, 152 (83.5 %) patients were operated on and 30 (16.5%) patients were treated conservatively (control group). Patients with decompensated bowel obstruction in the postoperative period were treated in the traditional and proposed way, which included lavage, oxygen therapy (Patent of Ukraine for utility model No. 81097) and enteral nutrition through an intubation tube. Intestinal lavage was performed with 0.9 % NaCl solution, enteral nutrition was started with the appearance of peristalsis with the help of "Peptamen" solution. An additional group of healthy individuals was also examined. For the purpose of serum cytokine status, TNF-a, IL-1β, IL-10 were determined by enzyme-linked immunosorbent assay using reagents manufactured by Ukrmedservice, Ukraine.
Results and Discussion. In patients with acute adhesive intestinal obstruction in the stage of decompensation treated by the traditional method, the content of the investigated cytokines (TNF-a, IL-1β, IL-10) continues to increase statistically significant up to 3 days postoperatively with a decrease after 5 days. The use of the comprehensive method of postoperative therapy in patients with decompensated acute intestinal obstruction implies a gradual decrease in the content of cytokines from 1 to 5 days postoperative, which corresponds to the positive dynamics of the results of general clinical trials and treatment.
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