Assessment of the spontaneous and induced by ligands tlr2 and tlr4 of products of inflammatory and antiinflammatory cytokines at patients with abdominal sepsis
DOI:
https://doi.org/10.11603/2414-4533.2020.1.10734Keywords:
abdominal sepsis, Toll-like receptors, cytokinesAbstract
The aim of the work: to study in dynamics synthesis inflammatory and antiinflammatory cytokines in patients with abdominal sepsis and their balance for assessment of the predictive importance.
Materials and Methods. 36 patients with abdominal sepsis are surveyed and operated. All patients were divided into 2 subgroups of comparison. The subgroup A included patients on the AS who were in a hospital (14±3) bed days. In this subgroup the optimum option of an outcome the AS was observed. The subgroup B of patients with AS was put by patients who were in a hospital (40±10) bed days. In this group development of a number of complications AS is noted. As group of control served the group of almost healthy donors.
Results and Discussion. Studying in dynamics (1–10 days) of a profile of cytokines (TNF, IL-6, IL-8, IL-10) which are produced by mononuclear cells of peripheral blood of patients with AS spontaneously and under the influence of TLR ligands, allowed to distinguish from the studied sick two subgroups: a favorable outcome the AS, with recovery during (14±3) bed days (the spontaneous and induced products – l–8 decreased by 10 days, and the products induced by ligands TLR antiinflammatory to cytokine l–10 raised by 7 days), and adverse, with recovery during (40±10) bed days (increases in the spontaneous and induced by ligands TLR of products SILT – 6 with 3 by 10 days and TLR induced by ligands products to IL-10 cytokine – up to 10 days). In patients with the favorable course of a disease the balance of pro-inflammatory cytokines increased for the account IL-8, and patients with the adverse course have IL-6 that the AS can serve as predictive criterion of an outcome and consequences while assessment of indicators of FNO was not informative.
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