Evaluation of the effectiveness of intravenous lidocaine hydrochloride in the intraoperative period

Authors

  • H. I. Posternak O. Bohomolets National Medical University, Kyiv
  • V. V. Skyba O. Bohomolets National Medical University, Kyiv
  • V. P. Korchak Kyiv City Clinical Hospital No. 1
  • S. V. Volchenko Kyiv City Clinical Hospital No. 1
  • O. O. Andreikiv Severodonetsk Town Multidisciplinary Hospital
  • A. V. Prosheltsov Kyiv City Clinical Hospital No. 1
  • O. O. Slotvynskyi Severodonetsk Town Multidisciplinary Hospital
  • H. M. Kulinchenko Severodonetsk Town Multidisciplinary Hospital

DOI:

https://doi.org/10.11603/2414-4533.2019.4.10722

Keywords:

general anesthesia, lidocaine hydrochloride, laparoscopic chondecystectomy, metalosteosynthesis

Abstract

The aim of the work: to prove the fact of intravenous administration of lidocaine hydrochloride during general anesthesia to reduce the total dose of narcotic analgesics without loss of analgesic effect.

Dynamic active prospective two-center study of two statistically homogeneous groups of patients was performed: in group 1 general anesthesia with fentanyl analgesia was performed, in group 2 – a combination of fentanyl and lidocaine hydrochloride. The study was performed during the anesthesiology of patients who underwent metalostesynthesis for multiple fracture with displacement of bone fragments of the upper extremity and patients undergoing laparoscopic cholecystectomy for cholelithiasis, chronic cholecystosis. It was found that the use of 1 % lidocaine hydrochloride in combination with fentanyl can significantly reduce the total dose the last one, namely the total dose of fentanyl in the group 1 was, on average, (8.63±0.72) µg/kg/h, whereas in group 2 managed to reduce the dose to (6.27±0.44) µg/kg/h to achieve adequate analgesia.

References

Dureux, M. (2014). Update in anesthesiology.

Vigneault, L., Turgeon, A.F., & Côté D. (2011). Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Can. J. Anesth., 58, 22-37.

Kalvi, T.N., & Uiliams, N.E. (2007). Farmakolohiia dlia anestezioloha [Pharmacology for anesthetist ]. Mizykov, V.M., & Tseitlina, A.M. (Eds). Moscow: BINOM [in Ukrainian].

http://erassociety.org

Eipe, N., Gupta, S., & Penning, J. (2016). Intravenous lidocaine for acute pain: an evidence-based clinical update. BJA Education, 16 (9). DOI: https://doi.org/10.1093/bjaed/mkw008

Louise Vigneault, Alexis F. Turgeon, Dany Côté, François Lauzier, Ryan Zarychanski, Lynne Moore, Lauralyn A. McIntyre, Pierre C. Nicole, & Dean A. Fergusson (2011). Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 58 (1), 22-37. DOI: https://doi.org/10.1007/s12630-010-9407-0

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Published

2020-01-11

How to Cite

Posternak, H. I., Skyba, V. V., Korchak, V. P., Volchenko, S. V., Andreikiv, O. O., Prosheltsov, A. V., … Kulinchenko, H. M. (2020). Evaluation of the effectiveness of intravenous lidocaine hydrochloride in the intraoperative period. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (4), 123–125. https://doi.org/10.11603/2414-4533.2019.4.10722

Issue

No. 4 (2019)

Section

REPORTS

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