Application of physical radiomodification in neoadjuvant therapy of rectal cancer

Authors

  • V. V. Kernychnyi M. Pyrohov Vinnytsia Memorial Medical University
  • A. I. Sukhodolia M. Pyrohov Vinnytsia Memorial Medical University
  • O. O. Pidmurniak M. Pyrohov Vinnytsia Memorial Medical University
  • S. A. Sukhodolia M. Pyrohov Vinnytsia Memorial Medical University

DOI:

https://doi.org/10.11603/2414-4533.2019.4.10713

Keywords:

rectal cancer, radiation therapy, low-frequency magnetic field, Ki-67

Abstract

The aim of the work: investigation of effective radiomodification by the local low-frequency magnetic field in the neadjuvant therapy for rectum cancer.

Materials and Methods. An investigation included 52 patients aged 41–80 years old (62.8±8.6): 27 (51.9 %) men and 25 (48.1%) women. The design of study is to conduct the searching of proliferate activity (Ki-67) in adenocarcinoma of the rectum and further neoadjuvant radiation therapy (NRT), total focal dose (TFD) 20–25 g (4–5 sessions to 5 g) using physical radio-modificatior (local low-frequency magnetic field). Later it was second study of proliferation activity (Ki-67) in adenocarcinomas and also surgery.

Results and Discussion. The expression of Ki-67 in the adenocarcinomas of the rectum to NRT and radiomodification by the local low-frequency magnetic field (RLLMF) was (15.5±5.9) % (p<0.05). Thus expression of Ki-67 in adenocarcinomas of the rectum decreased by 9.8 %. An index Ki-67 to NRT and RLLMF of the patients that have the degree differentiation of adenocarcinomas of the rectum G2 (n=43) was (24.8±9.4) %. The index of the patients that have the degree differentiation G3 (n=9) to NRT and RLLMF was (27.6±9.4) % (p>0.05). After NRT and RLLMF the patients of G2 (n=48) have Ki-67 of (15.0+-5.5) %. But the patients of G3 (n=4) have Ki-67 of (22.2±8.4) % (p=0.01). There was a significant difference in reducing the percantage of proliferation activity in subgroups of patients with moderately differentiated (G2) and low-differentiated adenocarcinoma (G3) after NRT and RLLMF.

Ki-67 index (n=43) G2 after NRT and RLLMF decreased by 9.3 % but index Ki-67 (n=4) G3 after NRT and RLLMF decreased by 5.4 %. However it should be noted that degree differentiation in 5 patients from G3 has changed to G2.

It was noted the moderate correlation of proliferation index from the expression level of Ki-67 till the treatment beginning and the expression of Ki-67 against a background of NRT and RLLMF (r=0,6; p<0,05).

Index of proliferation activity in the adenocarcinomas of the rectum of the old age and elderly patients (n=19) was almost equal (24.9±8.0) % and (26.0±10.8) %. After the end of NRT and RLLMF the average value of Ki-67 in the adenocarcinomas of the rectum of age subgroups was (16.0±5.8) % (n=33) and (14.3±6.1) % (n=19). Proliferation index of adenocarcinomas of the middle-aged patients decreased by 11.7 % but it was by 8.9 % (p<0.05) of the old age and elderly patients.

References

Starborg, M., Gell, K., Brundell, E., & Höög, C. (1996). The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. Journal of Cell Science, 109, 143-153. DOI: https://doi.org/10.1242/jcs.109.1.143

Gardes, J. (1990). Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. Seminars in Cancer Biology, 1, 99-106.

Schlüter, C., Duchrow, M., Wohlenberg, C., Becker, M.H., Key, G., Flad, H.D., & Gerdes, J. (1993). The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. The Journal of Cell Biology, 3, 513-522. DOI: https://doi.org/10.1083/jcb.123.3.513

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Published

2020-01-11

How to Cite

Kernychnyi, V. V., Sukhodolia, A. I., Pidmurniak, O. O., & Sukhodolia, S. A. (2020). Application of physical radiomodification in neoadjuvant therapy of rectal cancer. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (4), 67–72. https://doi.org/10.11603/2414-4533.2019.4.10713

Issue

No. 4 (2019)

Section

EXPERIENCE OF WORK

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