Structural changes of the microcirculatory bed of the duodenum at the Obstructive cholestasis
DOI:
https://doi.org/10.11603/2414-4533.2019.4.10711Keywords:
obstructive cholestasis, duodenum, microcirculatory bedAbstract
The aim of the work: to study morphologically the features of vascular remodeling of the microcirculatory bed of the duodenum at prolonged obstructive cholestasis.
Materials and Methods. Features of vascular remodeling of the microcirculatory bed of the duodenum at prolonged obstructive cholestasis were investigated morphologically. Оbstructive cholestasis was modeled by the ligation of the common bile duct. The microcirculatory bed of the duodenum was examined by the method of V. V. Kupriyanov after 3, 7, 14 and 28 days of simulated obstructive cholestasis.
Results and Discussion. Studies have shown that obstructive cholestasis leads to marked remodeling of the microcirculatory bed of the duodenum. In the early stages of the simulated pathology, there is a spasm of the arterial vessels of the hemomicrocirculatory bed and expansion of the capillary venules and venules, increasing their density. At 14 and 28 days, obstructive cholestasis is complicated by the enlargement of the lymphatic and venous vessels of the microcirculatory bed, the decrease in the number of hemocapillaries, hypoxia, dystrophic, necrobiotic, infiltrative and sclerotic processes in the duodenal wall.
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