Peculiarities of remodeling of vessels of hemomicrocirculatory testes bed at the postresection portal hypertension

Authors

  • M. S. Hnatjuk I. Horbachevsky Ternopil National Medical University
  • S. O. Konovalenko I. Horbachevsky Ternopil National Medical University
  • L. V. Tatarchuk I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2019.4.10708

Keywords:

postresection portal hypertension, testes, hemomicrocirculatory bed

Abstract

The aim of the work: to study the features of remodeling of the hemomicrocirculatory testesbed at postresection portal hypertension.

Materials and Methods. Morphologically studied hemomicrocirculatory bed testis of 45 rats, which were divided into 3 groups. The group 1 consisted of 15 intact animals, 2 – 15 rats after resection 31.5 % the liver parenchyma, 3 – 15 animals after removal of 58.1 % of the volume of the liver. Euthanasia of rats was performed by bloodletting in condition of thiopental anesthesia 1 month from the beginning of the experiment. The hemomicrocirculatory bed was filled with a mascara-gelatin mixture. The histological micropreparations of the testes determined the diameters of arterioles, capillary arterioles, hemocapillaries, capillary venules, venules, and microvascular density. Quantitative indicators were processed statistically.

Results and Discussion. It was found that resection of 58.1 % of the parenchyma of the liver led to the development of postresection portal hypertension.

The prolonged postresection portal hypertension leads to a pronounced narrowing of the offering (arterioles, precapillary arterioles), metabolic (hemocapillaries) units of the microhemocirculatory bed, and the expansion of capillary venules. The detected structural reconstruction of the microvessels depended on the volume of the resection liver.

References

Avtandilov, G.G. (2002). Osnovy kolichestviennoy patologicheskoy anatomii [Basis of quantitative pathological anatomy]. Moscow: Meditsyna [in Russian].

Bykov, A.D., & Dorogan, D.A. (2009). Sravnitelnaya effektivnost metodov drenirovaniya vnepechonochnykh zhelchnykh protokov pri mekhanicheskoy zheltukhe [Comparative efficacy of extrahepatic bile duct drainage methods for obstructive jaundice]. Vestn. Buryatskogo gosudarstvennogo universiteta – Herald of Buryat State University, 12, 152-154 [in Russian].

Hnatiuk, M.S., Tatarchuk, L.V., & Yasinovskyi, O.B. (2016). Morfometrychna otsinka osoblyvostei remodeliuvannia struktur dvanadtsiatypaloii kyshky pry rezektsii riznykh obiemiv pechinky [Morphometric evaluation of features of remodeling of structures of a duodenum at resection of different volumes of a liver]. Naukovyi visnyk Uzhhorodskoho universytetu. Seriia “Medytsyna” – Scientific Herald of Uzhhorod University. Series “Medicine", 1 (49), 3-5 [in Ukranian].

Lapach, S.N., Hubenko, A.V., & Babich, P.N. (2001). Statisticheskiye metody v mediko-biologicheskikh issledovaniyakh Excell [Statistical Methods in Excel Biomedical Research]. Kyiv: Morion [in Russian].

Pylypchuk, V.I. (2016). Varianty operatsiinykh vtruchan na zhovchovyvidnykh protokakh pry khronichnomu pankreatyti z oznakamy biliarnoi hipertenzii [Options for surgery on the bile ducts in chronic pancreatitis with signs of biliary hypertension]. Shpytalna khirurhiya – Hospital Surgery, 2, 27-31 [in Ukranian].

Reznikov, O.H. (2003). Zahalni etychni pryntsypy eksperymentiv na tvarynakh [General ethical principles of animal experiments]. Endokrynolohiia – Endocrynology, 8, 1, 142-145 [in Ukraіnian].

Sobazstiano, P., & di Molat, F. (2013). Pathophysiology of chronic damage. Acute and chronic pancreatitis. Turin: Editioni Minerva modica.

Yakobson T., Korjagin, J., & Vipp, N. (2014). Postoperative complication and mortality after major gastrointestinal surgery. Medicina, 50, 2, 111-117. DOI: https://doi.org/10.1016/j.medici.2014.06.002

Downloads

Published

2020-01-10

How to Cite

Hnatjuk, M. S., Konovalenko, S. O., & Tatarchuk, L. V. (2020). Peculiarities of remodeling of vessels of hemomicrocirculatory testes bed at the postresection portal hypertension . Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (4), 37–41. https://doi.org/10.11603/2414-4533.2019.4.10708

Issue

No. 4 (2019)

Section

EXPERIMENTAL INVESTIGATIONS

License

Authors who publish their work in Hospital Surgery. Journal by L. Ya. Kovalchuk agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  
  2. Лицензия Creative Commons
  3. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)