Healing of the cut wounds of the skin under the influence of nanomaterials of biodegradable wound healing
(experimental study)
DOI:
https://doi.org/10.11603/2414-4533.2019.2.10417Keywords:
cutaneous wound, polymer films, experimentAbstract
The aim of the work: to investigate the effect of nano-containing biodegradable wound on the healing of uncomplicated cutaneous wounds of the skin in the in vivo experiment.
Materials and Methods. The study was carried out using a biodegradable polymer film zinc-saturated polymer and hydrated fullerene C60 solution and Curasorb Zn wound dressing on 53 guinea pigs at the clinic-biological base “Vivarii” of the Ivano-Frankivsk National Medical University, in compliance with the sanitary and hygienic norms and rules of the European Convention on the Protection of Vertebrate Animals. The observation dates were 3, 7, 14 and 21 days. Performed planimetric, pathomorphological and microbiological.
Results and Discussion. Morphologically, for the third day in all studied groups, massive sites of necrosis, hemorrhage and edema of subepithelial soft tissues were observed. The area of the wound surface in animals of the group II decreased by 17.8 %, which is the best result compared with group І, and in animals of the group III the area of the wound before the 3rd day decreased by 25.8 %. The formation of granulation tissue in the 7th day in the group III of animals was more active than in animals of the group II, which was manifested by a greater number of newly formed capillaries and less severe inflammatory infiltration of the surgical intervention zone. At the 14th day of the experiment, the area of the wounds in the group I under study was (148.9±8.5) mm2, indicating a decrease of the area by 70.4 %. In the group II at the 14th day, the area of wounds decreased by 90.4 %, and in group ІІI there was complete epithelization.
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