Morphological changes in kidneys in conditions of accute peritonitis on the background of diabetes mellitus

Authors

  • I. Ya. Dzubanovsky I. Horbachevsky Ternopil State Medical University
  • B. M. Verveha Danylo Halytskyi Lviv National Medical University
  • S. R. Pidruchna I. Horbachevsky Ternopil State Medical University
  • N. A. Melnyk I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/2414-4533.2019.2.10416

Keywords:

acute general peritonitis, diabetes mellitus, morphological changes in the kidney

Abstract

The aim of the work: to investigate the morphological changes in the kidneys of experimental animals in a simulated acute general peritonitis on the background of diabetes mellitus compared to animals with experimental acute peritonitis.

Materials and Methods. 56 white rats were used in this work. Diabetes mellitus was modeled by intraperitoneal injection of streptozotocin by Sigmal brand at a rate of 7 mg per 100 g of animal weight, acute peritonitis – by administering 0.5 ml of 10 % captured fecal suspension to the abdominal cavity of the animals under study. Investigated kidney tissue 1, 3, 7 days from the beginning of peritonitis modeling.

Results and Discussion. In animals with acute general peritonitis, the pathomorphological changes were more pronounced on the background of diabetes mellitus: the vessels of the venous channel were slightly enlarged, were full-blooded, and visualized small perivascular hemorrhages. The vast majority of the outflow tubules were expanded, but their enlightenment was free of exudates. In the loops of Henle and the direct tubules, we observed a marked edema of the epithelium.

References

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Published

2019-09-10

How to Cite

Dzubanovsky, I. Y., Verveha, B. M., Pidruchna, S. R., & Melnyk, N. A. (2019). Morphological changes in kidneys in conditions of accute peritonitis on the background of diabetes mellitus. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (2), 42–47. https://doi.org/10.11603/2414-4533.2019.2.10416

Issue

No. 2 (2019)

Section

EXPERIMENTAL INVESTIGATIONS

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