SELECTION OF EXCIPIENTS FOR TABLETS CREATION WITH METHYLAMMONIUM 2-[(4-AMINO-5-PHENYL-4H-1,2,4-TRIAZOL-3-YL)THIO]ACETATE USING WET GRANULATION
DOI:
https://doi.org/10.11603/2312-0967.2019.1.9882Keywords:
1,2,4- triazole, tablets, excipients, wet granulationAbstract
The aim of the work. Studying of the excipients influence on the pharmaco-technological properties of methylammonium 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetate tablets, selection of the best compositions of them.
Materials and Methods. The equipment for getting tablets and determining of the pharmaco-technological characteristics: uniformity of mass, friability, disintegration of tablets, resistance to crushing of tablets was used. The influence of 16 excipients on the pharmaco-technological parameters of tablets was investigated.
Results and Discussion. The wet granulation method was used to obtain the tablets. In the process of selecting the previous composition of excipients, one of the dispersion analysis plans was used – a four-factor experiment based on the Graeco-Latin square. The excipients were divided into four groups: diluents, disintegrating agents, binders, glidants and lubricants. The influence of four groups of excipients on the pharmaco-technological characteristics of methylammonium 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetate tablets was investigated.
Conclusions. The combination of excipients for the following research on development obtaining of methylammonium 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetate tablets using wet granulation was found: sugar powder (diluent), sodium croscarmellose (disintegrating agent), 4 % solution PVP 17K (binder), sodium laurylsulfate (glidant and lubricant).
References
Panasenko OI, Knysh YG, Pruglo YeS. Pat. № 114571, Ukraine. Derivatives of 5-phenyl-4-amino-1,2,4-triazole-3-thione exhibiting diuretic activity. оpubl. 26.06.2017, Byul. № 12/2017; Ukrainian.
Hroshovyi TA, Belei NM, Kucherenko LI, Vasenda MM, Markiv NV, Tryhubchak OV, et al. [Optimization of techno-logical processes of drugs creation by means of mathemat-ical planning of experiment]. Farmatsevt chasop. 2007;1: 21-8. Ukrainian.
Hroshovyi TA, Martseniuk VP, Kucherenko LI, Vronska LV, Hurieieva SM. Mathematical planning of experiment in pharmacy. [Математичне планування експерименту при проведенні наукових досліджень в фармації] Ternopil: Ternopil State Medical University; 2008. Ukrainian.
State Pharmacopoeia of Ukraine in 3 vol., 2nd edition. [Державна Фармакопея України: в 3 т.] Kharkiv: State Enterprise “Ukrainian Scientific Pharmacopoeial Cen-ter for Quality of Medicines”; 2015.
Vasenda MM, Belei NM, Demchuk MB, Tryhubchak OV, Chubka MB, Hurieieva SM, et al. [The modern situation of the creation, manufacture and researches of tablet’s medicines. Report 1]. Farmatsevt chasop. 2009;4: 77-80. Ukrainian.
Parikh DM (Ed.). Handbook of Pharmaceutical Granula-tion Technology, 2nd edition. Boca Raton, FL, USA: Taylor & Francis Group, LLC; 2005.
Ruban OA, Pertsev IM, Kutsenko SA, Maslii YuS. Substances in the manufacture of drugs: teaching. manual for students of higher education [Допоміжні речовини у виробництві ліків: навч. посіб. для студентів вищ. фармац. навч. закл.] Kharkiv: Zoloti storinky; 2016. Ukrainian.
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