ACUTE TOXICITY OF 4-CARBOXYMETHYLPYRIDINIUM HEXAFLUOROSILICATE

Authors

  • I. O. Shyshkin Odesa National Medical University
  • O. L. Tymchyshyn Odesa National Medical University
  • V. O. Gelmboldt Odesa National Medical University

DOI:

https://doi.org/10.11603/2312-0967.2018.3.9319

Keywords:

caries prophylactic agents, 4-carboxymethylpyridinium hexafluorosilicate, acute toxicity.

Abstract

The aim of the work. Study of the toxicometric characteristics of 4-carboxymethylpyridinium hexafluorosilicate as a potential anti-caries preparation in an acute experiment on rats with oral administration.

Materials and Methods. A study of the acute toxicity of hexafluorosilicate 4-carboxymethylpyridinium was carried out on 27 male Wistar rats weighing 180–200 grams. The main criterion for quantifying the toxicity of 4-carboxymethylpyridinium hexafluorosilicate was LD50, which was determined using the least squares method. Also, the following hazard indicators were calculated: 1 / LD50 – median lethal dose (absolute toxicity), LD84 / LD16 – the range of lethal doses (zone of acute toxic effect), 1 / (LD50-S) – the total toxicity index and the S-function angle of inclination (variability of lethal doses). Statistical processing of the results was carried out using the «StatPlus 2009» software (AnalystSoft,USA, 2009).

Results and Discussion. The results of the acute toxicity determination of 4-carboxymethylpyridinium hexafluorosilicate show that this compound, in the oral route of administration, belongs to the III class of toxicity (slightly hazardous). Based on the variability of lethal doses, the studied hexafluorosilicate can be attributed to compounds that do not pose a high potential risk of the onset and development of poisoning. The calculated toxicity and hazard values of 4-carboxymethylpyridinium hexafluorosilicate show that it does not pose a particular danger to humans.

Conclusions. The acute toxicity of 4-carboxymethylpyridinium hexafluorosilicate in an experiment in rats at the oral route is 481.28 mg / kg, which allows the classification of this derivative to grade III toxicity (moderate toxic compounds).

Author Biographies

I. O. Shyshkin, Odesa National Medical University

post graduate student of Department of Pharmaceutical Chemistry in Odessa National Medical University

O. L. Tymchyshyn, Odesa National Medical University

PhD, Associate Professor of Department of General and Clinical Pharmacology in Odessa National Medical University

V. O. Gelmboldt, Odesa National Medical University

DS, Professor, Chief of Pharmaceutical Chemistry Department in Odessa National Medical University

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Published

2018-09-07

How to Cite

Shyshkin, I. O., Tymchyshyn, O. L., & Gelmboldt, V. O. (2018). ACUTE TOXICITY OF 4-CARBOXYMETHYLPYRIDINIUM HEXAFLUOROSILICATE. Pharmaceutical Review Farmacevtičnij časopis, (3), 80–84. https://doi.org/10.11603/2312-0967.2018.3.9319

Issue

No. 3 (2018)

Section

Pharmacological researches of biologically active substances

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