STUDY THE STRUCTURE OF DILTIAZEM AND BROMOCRESOL GREEN REACTION PRODUCT

Authors

  • M. I. Sulyma Danylo Halytsky Lviv National Medical University
  • V. V. Ogurtsov Danylo Halytsky Lviv National Medical University
  • Yu. M. Zhuk Zaporizhia State Medical University
  • S. O. Vasyuk Zaporizhia State Medical University
  • S. V. Khomyak Lviv Polytechnic National University

DOI:

https://doi.org/10.11603/2312-0967.2018.3.9316

Keywords:

diltiazem hydrochloride, bromocresol green, ionic associate, spectrophotometry.

Abstract

The aim of the work.  Selection and identification of the diltiazem hydrochloride аnd bromocresol green reaction product.

Materials and Methods. Diltiazem hydrochloride working standard, bromocresol green and the sample of final dosage forms were used.

Reagents and solvents: A standard sample of diltiazem hydrochloride, bromocresol green, acetone.

Analytical equipments: Spectrophotometer Specord Bruker Alpha (Bruker Optik GmbH, Ettlingen, Germany) using a prefix (full internal reflection) ATR (direct injection of substance), Spectrophotometer Specord 200 (Germany) (190-1100 nm).

Results and Discussion. It was experimentally established that diltiazem hydrochloride forms coloured ion-pair product with bromocresol green in acetone medium. IR-spectrum ion-pair complex corresponds to the sum of absorption of starting compounds with some differences, which confirm its formation. In ion-pair product in the region 3600–3400 sm-1 strips of phenolic –ОН appear with less intensity, which can be explained by the transformation of bromocresol green into the quinone structure. The product also has no absorption in the region 2370 cm-1 (R3N+ Cl- in diltiazem hydrochloride), which is explained by the formation of the ionic associate with bromocresol green, namely, the absorption is manifested in the form of a wider signal in the region 3200–2000 cm-1.

 

Conclusions. Presented analytical assay showed that diltiazem hydrochloride reacts with bromocresol green in a ratio of 1:1. It was also established and identified the structure of the product of reaction. Using IR- spectroscopy, it was confirmed that is known to be an ionic associate.

Author Biographies

M. I. Sulyma, Danylo Halytsky Lviv National Medical University

Teaching Assistant General, bioinorganic, physical and colloidal chemistry department, Danylo Halytsky Lviv National Medical University

V. V. Ogurtsov, Danylo Halytsky Lviv National Medical University

Head of General, Bioinorganic, Physical and Colloidal chemistry department, Danylo Halytsky Lviv National Medical University, PhD, Ass. prof.

Yu. M. Zhuk, Zaporizhia State Medical University

Teaching Assistant Analytical Chemistry Department, Zaporizhia State Medical University, PhD

S. O. Vasyuk, Zaporizhia State Medical University

Head of the Analytical Chemistry Department, Zaporizhia State Medical University, PhD, DSc, Professor

S. V. Khomyak, Lviv Polytechnic National University

Teaching AssistantInstitute of Chemistry and Chemical Technologies, Lviv Polytechnic National University, PhD

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Published

2018-09-06

How to Cite

Sulyma, M. I., Ogurtsov, V. V., Zhuk, Y. M., Vasyuk, S. O., & Khomyak, S. V. (2018). STUDY THE STRUCTURE OF DILTIAZEM AND BROMOCRESOL GREEN REACTION PRODUCT. Pharmaceutical Review Farmacevtičnij časopis, (3), 58–63. https://doi.org/10.11603/2312-0967.2018.3.9316

Issue

No. 3 (2018)

Section

Analysis of drugs

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