EXCIPIENTS CHOICE TO OBTAIN TABLETS BASED ON CARBAMAZEPINE AND THIOTRIAZOLINE BY WET GRANULATION METHOD

Authors

  • L. I. Kucherenko Zaporizhzhia State Medical University
  • G. R. Nimenko Zaporizhzhia State Medical University
  • Z. B. Moryak Zaporizhzhia State Medical University

DOI:

https://doi.org/10.11603/2312-0967.2017.3.8117

Keywords:

carbamazepine, thiotriazolin, tablets, excipients, wet granulation method, mathematical experiment planning.

Abstract

Message 2. Effect of excipients on the process of extrusion, surface quality and uniformity of tablets dosage with carbamazepine and thiotriazoline obtained by wet granulation method.

The aim of the work. Studying the influence of excipients on the pharmaco-technological parameters of carbamazepine tablets with thiotriazoline, obtained by the wet granulation method. Choosing the best excipients to get the optimal composition of pills with the thiotriazoline.

Materials and Methods. Medicinal substances – carbamazepine and thiotriazoline (1.5: 1), excipients (fillers, extenders, binders, lubricants). The tablets were made by wet granulation method. The influence of excipients on carbamazepine tablets with thiotriazoline was studied according to the following indices: resistance to crushing, erosion, decomposition, appearance of the surface after 6 months of storage.

Results and Discussion. According to the results of the dispersion analysis of experimental data, it has been established that the nature of the filler, binder, binder and lubricating excipients affects the stability of the tablets of carbamazepine with thiotriazolin to crushing, erosion, disintegration, appearance of the surface after 6 months of storage. Thus, lactose monohydrate has the best effect on the stability of the tablets for crushing among the fillers; the crossover chloride is among the chemists, among the binders is a 2 % solution of MC, among the lubricants is sodium laurylsulfate.

The slightest erosion of carbamazepine tablets with thiotriazolin is observed when used as a filler of MCC101, arupture agent – Crospovidone CL 10 binding – 2 % solution of MC, lubricating – calcium stearate.

The most rapid disintegration of pills of carbamazepine with thiotriazoline was used when sodium croscarmellose was used as lubricant, magnesium stearate and binding substances – starch paste. Fillers do not differ in their effects on the time of disintegration of tablets of carbamazepine with thiotriazolin. .

The potato starch and stearin acid provide the highest level of preservation of the surface color of the tablets of carbamazepine with thiotriazoline after 6 months of storage. Investigated fillers and binders to the same extent affect the indicated index.

Conclusions. The influence of 16 excipients on the pharmaco-technological properties (resistance to crushing, erosion, decomposition, appearance of the surface after 6 months of storage) of carbamazepine tablets with thiotriazolin was studied. According to the aggregate of the studied indices, the best combination of excipients for further study was selected in order to develop the optimal composition and technology of tablets of carbamazepine with thiotriazolin.

Author Biographies

L. I. Kucherenko, Zaporizhzhia State Medical University

head of the department of pharmaceutical chemistry, Zaporizhzhia State Medical University, Prof. Dr. of Pharmacy

G. R. Nimenko, Zaporizhzhia State Medical University

assistant professor of the department of pharmaceutical chemistry, Zaporizhzhia State Medical University

Z. B. Moryak, Zaporizhzhia State Medical University

associate professor of the department of pharmaceutical chemistry, Zaporizhzhia State Medical University, PhD

References

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Published

2017-10-04

How to Cite

Kucherenko, L. I., Nimenko, G. R., & Moryak, Z. B. (2017). EXCIPIENTS CHOICE TO OBTAIN TABLETS BASED ON CARBAMAZEPINE AND THIOTRIAZOLINE BY WET GRANULATION METHOD. Pharmaceutical Review Farmacevtičnij časopis, (3), 39–46. https://doi.org/10.11603/2312-0967.2017.3.8117

Issue

No. 3 (2017)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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