REGARDING L-LYSINE 3-METHYL-1.2.4-TRIAZOLE-5-THIOACETATE STANDARDIZATION

Authors

  • L. I. Kucherenko Zaporizhzhia State Medical University, SPA Farmatron, Zaporizhzhia
  • O. S. Bidnenko Zaporizhzhia State Medical University, SPA Farmatron, Zaporizhzhia
  • G. I. Tkachenko Zaporizhzhia State Medical University, SPA Farmatron, Zaporizhzhia

DOI:

https://doi.org/10.11603/2312-0967.2017.1.7541

Keywords:

API, L-lysine 3-methyl-1, 2, 4-triazole-5-thioacetate, standardization, identication, quantitative assay.

Abstract

The aim of the work. Developing the methods of standardization, including identi cation and quantitative assay, of L-lysine 3-methyl-1.2.4-triazole-5-thioacetate an active pharmaceutical ingredient (API) by physico-chemical methods.


Research Methods. For identi cation of L-lysine 3-methyl-1.2.4-triazole-5-thioacetate we invited and conducted method of spectroscopic studies. During of operation we selected optimal condition for the analyses of L-lysine 3-methyl-1.2.4-triazole-5-thioacetate in different concentration. We picked up concentration for our results that absorption line must be in the UV area 238 nm.


Results and Discussion. The results of the studies show that the absorption characteristic in UV area of L-lysine 3-methyl-1.2.4-triazolyl-5-thioacetate an shoulder of 238 nm.


Conclusions. We developed methods to identi cation and quantitative during operation of substance. In further time we have plan to introduce methods of qualitative and quantitative analysis substance to MCQ drugs L-lysine 3-methyl-1.2.4-triazolyl-5-thioacetate.

Author Biographies

L. I. Kucherenko, Zaporizhzhia State Medical University, SPA Farmatron, Zaporizhzhia

Doctor of Pharmacy, Professor, Head of the Department of Pharmaceutical Chemistry of Zaporizhzhia State Medical University

O. S. Bidnenko, Zaporizhzhia State Medical University, SPA Farmatron, Zaporizhzhia

Assistant of the Department of Pharmaceutical Chemistry

G. I. Tkachenko, Zaporizhzhia State Medical University, SPA Farmatron, Zaporizhzhia

PhD in Pharmaceutical sciences of the Department of Pharmaceutical Chemistry

References

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Published

2017-03-24

How to Cite

Kucherenko, L. I., Bidnenko, O. S., & Tkachenko, G. I. (2017). REGARDING L-LYSINE 3-METHYL-1.2.4-TRIAZOLE-5-THIOACETATE STANDARDIZATION. Pharmaceutical Review Farmacevtičnij časopis, (1), 28–31. https://doi.org/10.11603/2312-0967.2017.1.7541

Issue

No. 1 (2017)

Section

Analysis of drugs

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