RESEARCH ON THE STABILITY OF «PHYTOPROST» SUPPOSITORIES DURING STORAGE
DOI:
https://doi.org/10.11603/2312-0967.2017.1.7526Keywords:
suppositories, stability, prostate.Abstract
The aim of the work. Research on the stability of “Phytoprost” suppositories during storage.
Materials and Methods. The objects of research were “Phytoprost” suppositories which contain a dry plant extracts Sabal palm fruit, Nettle root and Pumpkin seed in their composition, and were made from solid fat by moulding. During storage of the suppositories using physical, physico-chemical, pharmaco-technological, microbiological and analytical methods the following indicators in accordance with the requirements of the State Pharmacopoeia of Ukraine were determined: appearance, average weight, disintegration time, melting point, pH, sterols content, microbiological purity.
Results and Discussion. Studies showed that the suppositories are stable within 1 year when stored in a dry, dark place at room temperature, and within 2 years when stored in a dry, dark and cool place.
Conclusions. The investigations for studying stability of the rectal suppositories "Phytoprost" for benign hyperplasia treatment during storage were made. It was proven that all indicators of the preparation quality into the norm, that listed in the project developed quality control methods. The storage mode of ''Phytoprost" suppositories was established. It is within 2 years in a dry dark cool place.
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