MODERN STATE OF CREATION, PRODUCTION AND RESEARCH OF DRUGS. Message 24. Osmotic drug release and delivery systems: design, characterization and classification

Authors

  • M. B. Demchuk I. Horbachevsky Ternopil State Medical University
  • M. B. Chubka I.Horbachevsky Ternopil State Medical University
  • L. V. Vronska I.Horbachevsky Ternopil State Medical University
  • T. A. Hroshovyi I.Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/2312-0967.2016.3.6822

Keywords:

osmotic systems, osmotic agents, semi-permeable membrane, drugs

Abstract

Introduction. Development of new drugs is a priority direction of modern pharmaceutical technology in the world. Modified release drugs that characterized by changes in the mechanism and type of release of active pharmaceutical ingredients (APIs) of the dosage form are perspective concerning development. The drug release can be modulated by different ways but the most of novel drug delivery systems are prepared using matrix, reservoir or osmotic principle. Osmotic drug delivery technique is the most interesting and widely acceptable among all other technologies used for the same.

Osmotic drug delivery systems use offer distinct and practical advantages over other means of delivery. The following advantages have contributed to the popularity of osmotic drug delivery systems.

  • The delivery rate of zero-order is achievable with osmotic systems.
  • Delivery may be delayed or pulsed, if desired.
  • Higher release rates are possible with osmotic systems compared with conventional diffusion-controlled drug delivery systems.
  • The release rate of osmotic systems is highly predictable and can be programmed by modulating the release control parameters.
  • For oral osmotic systems, drug release is independent of gastric pH and hydrodynamic conditions.
  • The release from osmotic systems is minimally affected by the presence of food in gastrointestinal tract.

Disadvantages of osmotically controlled drug delivery system are expensive, chances of toxicity due to dose duping, rapid development of tolerance, hypersensitivity reaction may occur, integrity and consistency are difficult, release of drug depends on size of hole, thickness of membrane, surface area, composition of membrane.

Development of osmotic drug delivery systems was pioneered by Alza and it holds major number of the patents analyzed and also markets several products based on osmotic principle. These systems can be used for both route of administration i.e. oral and parenterals. Oral osmotic systems are known as gastro-intestinal therapeutic systems. Parenteral osmotic drug delivery includes implantable pumps.

Oral osmotically driven systems have primarily evolved from being device concepts for the delivery of veterinary medicines, namely Rose-Nelson, Higuchi-Leeper and Higuchi-Theeuwes pumps. Using osmotic pressure as the energy source, the semi-permeable membrane controls water inflow, generating hydrodynamic pressure inside the device and, thereby controlling drug delivery. All these technologies have in common the semi-permeable membrane controlling the drug delivery rate.

Basic components of osmotically drug delivery system are drug, osmotic agent, semi permeable membrane, pore forming agents, plasticizers. Osmogent are essential ingredient of osmotic pump, usually is ionic compounds consisting of either inorganic salts or hydrophilic polymers and carbohydrates. Generally combination of osmogent is used to achieve desired osmotic pressure within the device.

         The semi permeable membrane should be a stable both to the outer inner environment of the device. The membrane must be sufficiently rigid so as to retain its dimensional integrity during the operational lifetime of the device.

         Factors affecting the release rate of drug from osmotic drug delivery system are solubility, osmotic pressure, delivery orifice, membrane type.

In recent years, controlled drug delivery system has been recognized as an attractive niche for the pharmaceutical and health industry.

Conclusions. Classification, basic requirements, approaches to the development of osmotic drug release and delivery systems are considered.

Author Biographies

M. B. Demchuk, I. Horbachevsky Ternopil State Medical University

I.Horbachevsky Ternopil State Medical University

M. B. Chubka, I.Horbachevsky Ternopil State Medical University

I.Horbachevsky Ternopil State Medical University

L. V. Vronska, I.Horbachevsky Ternopil State Medical University

I.Horbachevsky Ternopil State Medical University

T. A. Hroshovyi, I.Horbachevsky Ternopil State Medical University

I.Horbachevsky Ternopil State Medical University

References

Cysuev B. B. Suchasnyy stan doslidzhenʹ rozrobok v oblasti innovatsiynykh likarsʹkykh form yikh modyfikatsiy / B. B. Sysuyev, I. V. Pletnʹova // Visnyk VolhHMU - 2014. - Vyp. 4 (52). - S. 7-12.

Leonova M. V., Bilousov Yu. B. Likarsʹki formy z modyfikovanym vyvilʹnennyam i systemy dostavky likiv. - M .: Litterra, 2011. - 656 s.

Controlled release drug delivery systems / D. Bhowmik, H. Gopinath, B. P. Kumar [et al.] // Journal “The Pharma Innovation”. – 2012. – Vol. 1. – N. 10. – P. 24-32.

Ajay B. M. Controlled porosity osmotic pump tablet-an overview / B. M. Ajay, R. Prasad, R. J. Vijaya // Journal of pharmaceutical research and health care. – 2010. – Vol. 2 (1). – P. 114-126.

Verma R. K. Formulation aspects in the development of osmotically controlled oral drug delivery systems / R. K. Verma, D. M. Krishna, S. Garg // Journal of Controlled Release. – 2002. – № 79. – Р. 7-27.

Osmotically controlled drug delivery system with associated drugs / B. P. Dupta, N. Thakur, N. P. Jain [et. al.] / J. Pharm. Pharmaceut Sci. – 2010. – Vol. 13 (3). – P. 571-588.

Deepak Singla Osmotic pump drug delivery – a novel approach / Deepak Singla, Sl. Hari Kumar, Nirmala // International Journal of Research in Pharmacy and Chemistry. – 2012. – Vol. 2 (2). – P. 661-670.

Farheen F. A Review on Osmotically Regulated Systems / F. Farheen, S. Bharadwaj // PharmaTutor. – 2014. – Vol. 2(5). – P. 51-64.

Advances in osmotic drug delivery system / Ch. Keshari Sahoo, S. Ram Mohan Rao, M. Sudhakar [et al.] / Journal of Chemical and Pharmaceutical Research. – 2015. – Vol. 7 (7). – P. 252-273.

Ramakant G. An Overview on Osmotically Driven Systems / G. Ramakant, P. Sanjay / Int. J. Pharm. Sci. Rev. Res. – 2015. – Vol. 31 (2). – P. 96-106.

Formulation aspects in development of controlled porosity osmotic pump tablet / H. Rajendra Mene, Nikhil R. Mene, D. R. Parakh [et al.] / Pharmaceutical and Biological Evaluations. – 2016. – Vol. 3. – Р. 1-18.

Osmotic pump drug delivery system: a noval approach / K. Singh, M. k. Walia, Dr. G. Agarwal [et al.] / Journal of Drug Delivery & Therapeutics. – 2013. –Vol. 3 (5). – P. 156-162.

KhairnarAshwini B. An overview on osmotic drug delivery system / B. KhairnarAshwini, S. B. Gondkar, R. B. Saudagar // International Journal of Universal Pharmacy and Bio Sciences. – 2015. – Vol. 4 (6). – P. 121-135.

Osmotic drug delivery systems: a review / MS D D Vishwakarma, Dr. M R Patel, Dr. K R Patel [et al.] // International Journal of Drug Formulation and Research. – 2001. – Vol. 2 (3). – P. 14-26.

A review on recent innovation in osmotically controlled drug delivery system / N. R. Gupta, A. Mishal, Yo. Bhosle [et al.] // Indian Journal of Pharmaceutical and Biological Research. – 2014. – Vol. 2 (2). – P. 117-129.

Mathur M. A Review on Osmotic Pump Drug Delivery System / Mathur M., Mishra R // Int J Pharm Sci Res. – 2016. – Vol. 7 (2). – P. 453-471.

Ahuja N. Osmotic-Controlled Release Oral Delivery System: An Advanced Oral Delivery Form / N. Ahuja1, V. Kumar, P. Rathee // The Pharma Innovation. – 2012. – Vol. 1. – №. 7. – P. 116-124.

A review on controlled porosity osmotic pump tablets and its evaluation / Ch. Keshari Sahoo, N. Kanta Sahoo, S. Ram Mohan Rao [et al.] // Bulletin of Faculty of Pharmacy, Cairo University. – 2015. – Vol. 53 (2). – P. 195-205.

Prajapati H. M. A review on recent innovation in osmotically controlled drug delivery system / H. M. Prajapati, S. T. Prajapati, C. N. Patel // International Journal of Pharmaceutical Research and Bio-science. – 2012. – Vol. 1 (3). – P. 158-194.

Overview of past and current osmotic drug delivery systems / M. S. Thorat, P. S. Anita, R. Virprasad [et al.] // Int J Pharm Chem Sci. – 2012. –Vol. 1(3). – P. 743–753.

Bhupinder S. Osmotically controlled oral drug delivery system / S. Bhupinder, А. Sharry, S. Ramanseep // Pharma Bizz. – 2007. – Vol. 2. – P. 22-28.

Udawant S. V. A review: osmotic drug delivery system / S. V. Udawant, S. B.Gondkar, R. B. Saudagar // World Journal of Pharmaceutical Research. – 2015. – Vol. 4 (3). – P. 1787-1801.

Edavalath S. A Review on Controlled Porosity Osmotic Pump Tablets / S. Edavalath, B. Prakash Rao // International Journal for Pharmaceutical Research Scholars. – 2013. – Vol. 2 (4). – P. 1787-1801.

Implantable Drug Delivery System: A Review / Mohammad Zaki A. J., S. K. Patil, D. T. Baviskar [et al.] // International Journal of PharmTech Research. – 2012. – Vol. 4. – №. 1. – Р. 280-292.

A review on novel osmotically controlled drug delivery system / D. Sharma, D. Kumar, M. Singh [et al.] // Indian Journal of Pharmaceutics. – 2012. –Vol. 3 (2). – P. 97-105.

Osmotic Pump: A Reliable Drug Delivery System / P. H Nikam, J. A. Kareparamban, A. P Jadhav [et al.] // Research Journal of Pharmaceutical, Biological and Chemical Sciences. – 2012. – Vol. 3 (3). – P. 478-493.

Review – Osmotic drug delivery system current scenario / R. S. Thakor, F. D. Majundar, J. K. Patel [et al.] // Journal of Pharmacy Research. – 2010. – № 3. – Р. 771-775.

A review on osmotically regulated devices / G. Piyush, R. Pankaj, A. Dabeer [et al.] // International Journal of Pharmacy & Life Sciences. – 2010. – Vol. 1 (6). – P. 302-312.

A review on osmotically regulated devices / P. Bharat, M. Brajesh, Ya. Virendra [et al.] / The pharma innovation. – 2012. – Vol. 1 (4). P. 48-56.

Oral osmotically driven systems, 30 years of development and clinical use / M. Vincent, O. Joerg, L. Nicoletta [et al.] // Eur J PharmBiopharm. –2009. –Vol. 73 (3). – P. 311-323.

Downloads

Published

2016-10-28

How to Cite

Demchuk, M. B., Chubka, M. B., Vronska, L. V., & Hroshovyi, T. A. (2016). MODERN STATE OF CREATION, PRODUCTION AND RESEARCH OF DRUGS. Message 24. Osmotic drug release and delivery systems: design, characterization and classification. Pharmaceutical Review Farmacevtičnij časopis, (3), 84–88. https://doi.org/10.11603/2312-0967.2016.3.6822

Issue

No. 3 (2016)

Section

Review

License

The authors who publish their materials in this journal agree with the following terms:

  • Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal Результат пошуку зображень за запитом "CC-BY logo".
  • Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.

Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).