DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF CAPSULATED DRUG BASED ON AMBROSIA AND HONEY POWDER

Authors

  • B. Т. Kudryk National University of Pharmacy
  • O. I. Тykhonov National University of Pharmacy
  • O. S. Shpychak National University of Pharmacy

DOI:

https://doi.org/10.11603/2312-0967.2016.3.6819

Keywords:

ambrosia, honey powder, physico-chemical properties, «Api-Immuno-Vit» capsules, immuno-modulatory action

Abstract

Announcement 1. Research of organoleptic and physico-chemical indicators of the quality of ambrosia and honey powder

 Introduction. One of the most important part of health is preservation of immunological protection concerning necessary level, which conditions actuality of creation of new effective immunostimulating means. Devices of natural origin play important role, which profitably differ from synthetic immunostimulators by means of biological  affinity to tissues of body, which are more popular concerning effectiveness in the market of medicines.

New standardized medical substances of produces of beekeeping  are deserved  of great attention – ambrosia and honey powder. For the first time they were offered  for development of new domestic medicines at National Pharmaceutical University. According to it, actual is creation of scientific – practical approaches to development of composition and technology of capsulated medicine of immunostimulating action based on  above substances, which  determined solution of problem of profilactics and treatment of sick people containing immunopathologies.

Methods of research. Research of ambrosia and substance of honey powder provided conduction of analysis of indicators of their quality in accordance with   expertise and their certification. In the course of analysis it was revealed, that  in accordance with   technical conditions  DSТU 7074: 2009, GОSТ 31776-2012 and ТU U 10.8-39834691-001: 2015 every single batch of research susbstances is submitted to verification concerning state of packing and marking, as well as concerning organoleptic and physico – chemical indicators.

Gradually basic requirements of safety in case of production of ambrosia and honey powder and their pre - packing were determined, аs well as admitted levels of toxic elements, pesticides and radionuclides in ambrosia and toxic elements, pesticides and antibiotics in substance of honey powder are determined. Tests concerning microbiological purity of ambrosia and honey powder and verification of fitness of these methodics were conducted in accordance with requirements of State pharmacopeia of Ukraine (SPU).

Results and discussion. According to results of conducted experiments, some  differences  in national and interstate requirements of indicators of quality of ambrosia were established. By the way, mass  part of water in accordance with national standard must be within 5,0 to 8,0 %, in comparison with unlike from 18,0%, admitted in  GОSТ 31776-2012. Мass part of  flavonoid compounds in national standard must be 2,5 %, it means by 2 %  more than  normative indicators, determined in comparable  GОSТ. Indicator of concentration of  hydrogen iones (рН) concerning national requirements also has considerable  differences and is within  3,5 to 5, when by interstate  requirements norm of current indicator must be no more than  3,0, which causes the alteration of environment from acid to  acescent, and reduction of acidity, in it’s turn  can have considerable impact on reduction of persistence of ambrosia to  fermentation and loss of it’s stability.

Researches also testify that experimental samples of ambrosia and honey powder concerning results of conducted organoleptic, physico – chemical and microbiological researches completely comply  to requirements which are appropriate to regulations, and data of substance can be used later as  acting substances in composition of developed medicine.

So, possibility of application of produces of beekeeping and their standardized substances as acting substances exists in order to develop apimedicines later. Especially acute problem of quality of current raw materials exists. It has to do with requirements concerning SPU and national standards (DSТU, ТU), control of quality and safety. Besides, organoleptic and physico - chemical indicators suggest also determination of  extremely admitted remnants of pesticides, heavy metals, radionuclides, antibiotics and conduction of tests concerning microbiological purity.

Conclusions. Research of study of organoleptic and physico – chemical indicators of quality of ambrosia and standardized substance of honey powder was conducted,  above components are included to composition of developed capsules «Api-Immuno-Vit»  of immunomodulatory action, contents of toxic elements, pesticides, radionuclides and antibiotics in experimental samples of acting substances were determined. In case of comparison of interstate and national requirements with quality of ambrosia, desparity in such as principally important indicators as : mass part of water, concentration of hydrogen iones, mass part of flavonoid compounds and crude protein were established.

Experimentally it was proved, that mixture consisting of biologically active substances of ambrosia and honey powder containing determined auxiliary  substances allows to receive granules for creation of capsulated «Api-Immuno-Vit» of immunomodulatory action.

Author Biographies

B. Т. Kudryk, National University of Pharmacy

Aspirant of the Department of Technology of Perfume and Cosmetics, National University of Pharmacy

O. I. Тykhonov, National University of Pharmacy

Laureate of the State Prize of Ukraine in science and technology, Academician Ukrainian Academy of Sciences, Honoured Worker of Science and Engineering of Ukraine, Doctor of Pharmacy, Honoured Professor

O. S. Shpychak, National University of Pharmacy

Doctor of Pharmacy, Ph.D., Associate professor of Head of Drugs Technology Department named after D.P. Salo, National University of Pharmacy

References

Zemskov A.M., Zemskov V.M., Zhurihina I.I., Ilina E.V., Karyakin A.V., Zemskova V.A. Types of immuno disorders in case of different illnesses // Russian Medical magazine (Immunology). – 2012. – № 3. – P. 82-85.

Morozov S.Yu. Immunocorrection and principles of it’s application // Russian medical magazine (Immunology). – 208. – № 4. – P. 242-243.

Pestun I. V., Mnushko Z. N., Tolochko V. M. Marketing researches of group of medicines – immunomodulators // Pharmasict. – 1998. – № 23. – P. 23-28.

State register of medical means of Ukraine [Electronic resource] / MHC of Ukraine ; head editor N. I. Sharikina. – K. : PC WORLD UKRAINE, 2016. – Regime of access : http://drlz.com.ua.

Compendium 2015 – Medicines / head editor V. N. Kovalenko. – K. : MORION, 2015. – 2360 p.

Rx–index™ – Classificator of medicines. – K. : Publishing house «Pharmacist – practicionner», 2011. – 928 p.

Yakovleva L.V. Study of pharmacodynamics of new immunotropic means «Aflufit» / L.V. Yakovleva, O.D. Nemyatih, O.Yu. Koshova // Pharmaceutical magazine. – 2010. – № 5. – P. 42-46.

Caruso T.J. Treatment of the common cold with Echinacea: a structured rewiew / T.J. Caruso, J.M. Gmaltney // Clin. Infect. Dis. – 2005. – Vol. 40. – P. 807-810.

DSTU 7074:2009 «Perga». Technical conditions. – K.: Stateconsumptionstandard of Ukraine, 2010. – 16 p.

Interstate Standardized GOST 31776-2012 «Perga». Technical conditions. – M.: FGUP «Standardinform», 2013. – 15 p.

TU U 10.8–39834691–001:2015 «Medicine powder» // Ministry of development of economy of Ukraine. – K., 2015. – 25 p.

Shpychak O. S. Theoretical and experimental foundations of composition and development of technology of apimedicines and sportive medicines for application : synopsis of thesis on competition of scientific degree of doctor of pharmaceutical science // O.S. Shpychak. – Kharkiv, 2016. – 45 p.

Yudin, A. I. Innovative technology and constructive particularities of equipment for reception of nourished powders : monography / A. I. Yudin. H., 2010. – 140 p.

State Pharmacopeia of Ukraine / DP «Scientific center of experts of pharmacopeia». – first edition. – H. : RIREG, 2001. – 556 p.

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Published

2016-10-28

How to Cite

Kudryk B. Т., Тykhonov O. I., & Shpychak, O. S. (2016). DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF CAPSULATED DRUG BASED ON AMBROSIA AND HONEY POWDER. Pharmaceutical Review Farmacevtičnij časopis, (3), 11–17. https://doi.org/10.11603/2312-0967.2016.3.6819

Issue

No. 3 (2016)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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