SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF 5-INDOLIDENERHODANINES
DOI:
https://doi.org/10.11603/2312-0967.2024.4.15010Keywords:
indole, thiazolidinones, antimicrobial activity, cytotoxicityAbstract
The aim of the work - to synthesize 5-inolidenerhodanines and investigate their anticancer activity and cytotoxicity.
Materials and Methods. During the research, organic synthesis methods were used, and physicochemical analysis of the synthesized compounds was performed. Antimicrobial activity was determined by the agar diffusion method. Cytotoxicity was assessed based on MTT assay data.
Results and Discussion. As a result of screening for antimicrobial activity, compounds with a noticeable effect on gram-positive strains of microorganisms, particularly staphylococci that form biofilms (MIC 0.93 mM), were identified. The studied compounds had low cytotoxicity on tumor, normal, and pseudonormal cell lines.
Conclusions. The results indicate the noticeable antimicrobial activity of rhodanine derivatives with an indole fragment in the molecules, which indicates the prospects for an in-depth study of this class of compounds.
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