THE SCREENING RESEARCH OF ANTIHYPOXIC PROPERTIES OF THE PHARMACEUTICAL COMPOSITION BASED ON L-CARNITINE FOR CORRECTION OF FETOPLACENTAL INSUFFICIENCY

Authors

DOI:

https://doi.org/10.11603/2312-0967.2023.1.13912

Keywords:

hypoxia, fetoplacental insufficiency, antihypoxants, pharmaceutical composition, L-carnitine

Abstract

The aim of the work. To determine antihypoxic properties of pharmaceutical composition (PhC) based on L-carnitine.

Materials and Methods. The researching of antihypoxic properties of the PhC based on L-carnitine has been fulfilled on two experimental models of acute hypoxia which were applied in non-line mice males (Mus musculus). The PhC has been introduced to animals during 15 days, daily and one hour before tests for detection of antihypoxic activity to be carried out; the reference drug – Mexikor® – has been introduced to mice of positive control group.

Results and Discussion. It has been determined the L-carnitine based PhC in a dose of 25 mg/kg was demonstrated the highest antihypoxic activity on the model of acute normobaric hypoxia with hypocapnia. Its activity was 31 % which corresponded to the drug of comparison Mexicor® in a dose of 16 mg/kg. More expressed antihypoxic activity of PhC based on L-carnitine in a dose of 25 mg/kg has been detected on the model of acute hemic hypoxia. This efficiency was 41 % and was a little over comparing with Mexicor® in a dose of 16 mg/kg.

Conclusions. It has been determined, L-carnitine based PhC in a dose of 25 mg/kg administrated intragastrically has demonstrated more expressed antihypoxic activity on the model of acute hemic hypoxia comparing with reference drug Mexicor® in a dose of 16 mg/kg (41 % vs 33 %). The prophylactic administration of PhC based on L-carnitine in a dose of 25 mg/kg has increased resistance of animals to hypoxic conditions. The expressed antihypoxic activity of PhC based on L-carnitine has been determined on the acute hemic hypoxia model which confirmed the perspectivity of further pharmacological investigations for using in medicine with the aim to prevent the consequences associated with fetoplacental insufficiency.

Author Biographies

I. V. Volokhov, V. Danilevsky Institute for Endocrine Pathology Problems of National Academy of Medical Science of Ukraine, National University of Pharmacy

Junior Researcher of the Department of Pathomorphology and Genetics of Endocrine Diseases, PhD-student, Department of Physiology and Pathological Physiology

V. A. Rybak, National University of Pharmacy of the Ministry of Health of Ukraine

DSc (Biology), Professor of the Department of Physiology and Pathological Physiology

L. Yu. Sergienko, V. Danilevsky Institute for Endocrine Pathology Problems of National Academy of Medical Science of Ukraine, National University of Pharmacy

DSc (Medicine), Professor, Leading Researcher of the Department of Pathomorphology and Genetics of Endocrine Diseases

S. P. Kustova, V. Danilevsky Institute for Endocrine Pathology Problems of National Academy of Medical Science of Ukraine, National University of Pharmacy

PhD (Pharmacy), Senior Researcher, Head of the Pharmaceutical form Technology Sector of the Analytical and Physicochemical Research Laboratory

T. V. Matvieieva, V. Danilevsky Institute for Endocrine Pathology Problems of National Academy of Medical Science of Ukraine, National University of Pharmacy

Junior Researcher of the Pharmaceutical form Technology Sector of the Analytical and Physicochemical Research Laboratory

T. V. Bondarenko, V. Danilevsky Institute for Endocrine Pathology Problems of National Academy of Medical Science of Ukraine, National University of Pharmacy

Senior Researcher of the Department of Pathomorphology and Genetics of Endocrine Diseases

M. O. Boiko, V. Danilevsky Institute for Endocrine Pathology Problems of National Academy of Medical Science of Ukraine, National University of Pharmacy

PhD (Pharmacy), Senior Researcher of the Pharmaceutical form Technology Sector of the Analytical and Physicochemical Research Laboratory

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Published

2023-03-30

How to Cite

Volokhov, I. V., Rybak, V. A., Sergienko, L. Y., Kustova, S. P., Matvieieva, T. V., Bondarenko, T. V., & Boiko, M. O. (2023). THE SCREENING RESEARCH OF ANTIHYPOXIC PROPERTIES OF THE PHARMACEUTICAL COMPOSITION BASED ON L-CARNITINE FOR CORRECTION OF FETOPLACENTAL INSUFFICIENCY. Pharmaceutical Review Farmacevtičnij časopis, (1), 50–57. https://doi.org/10.11603/2312-0967.2023.1.13912

Issue

No. 1 (2023)

Section

Pharmacological researches of biologically active substances

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