ANALYSIS OF PHARMACOTHERAPY OF ARTERIAL HYPERTENSION AT THE INPATIENT STAGE

Authors

DOI:

https://doi.org/10.11603/2312-0967.2023.2.13871

Keywords:

arterial hypertension, antihypertensive drugs, adherence to treatment, pharmaceutical care

Abstract

The aim of the work. To analyze the prescription of antihypertensive drugs of different groups in hospital conditions, the adherence of patients to treatment; to determine the role of the pharmacist in increasing the effectiveness of the treatment of people with arterial hypertension.

Materials and Methods. A retrospective analysis of 34 medical records of inpatients who were treated in Ternopil City Communal Hospital No. 3 during 2022 with a diagnosis of "Arterial hypertension, II stage" was conducted as was also the analysis of questionnaires (supplemented Morisky-Green questionnaire (MMAS-8)).

Results and Discussion. The analysis of pharmacotherapy showed that patients mostly received combined antihypertensive therapy (79.4 %), the share of patients who received ACE inhibitors was 61.8 %, diuretics – 53.0 %, calcium ion antagonists and beta-blockers – 20.6 %. As a result of the analysis of the questionnaires, it was found that the high level of compliance was in 17.6 %, average level in 14.7 % of patients, and the low one (67.6 %) prevailed, especially in the older age group.

Conclusions. A low level of adherence to treatment was recorded in the vast majority of patients. Pharmacists within the framework of the current protocol need to work with patients with arterial hypertension to increase adherence to treatment.

Author Biographies

O. Ye. Samohalska, I. Horbachevsky Ternopil National Medical University

DSс (Medicine), Professor, Head of the Department of Clinical Pharmacy

O. V. Shmanko, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), assistant of the Department of Clinical Pharmacy

Z. P. Mandziy, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), Associate Professor of the Department of Clinical Pharmacy

I. M. Markiv, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), Associate Professor of the Department of Clinical Pharmacy

V. F. Tiurina, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), Associate Professor of the Department of Clinical Pharmacy

I. V. Meretska, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), Associate Professor of the Department of Clinical Pharmacy

N. V. Lobanets, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), Associate Professor of the Department of Clinical Pharmacy

Ye. O. Halinchynska, I. Horbachevsky Ternopil National Medical University

student of the Department of Clinical Pharmacy

References

Hypertension. [Internet]. World Health Organization; [2023; cited 2023 May 11]. Available from: https://www.who.int/news-room/fact-sheets/detail/hypertension.

Sirenko YuM, Lutai MI, Nesukai OH [Control of arterial hypertension in Ukraine: conclusions of experts]. Zdorovia Ukrainy. 2018. Available from: https://health-ua.com/article/33340-kontrol-arteralno-gpertenz-v-ukran-visnovki-ekspertv. Ukrainian.

Electronic document “An updated and adapted evidence-based clinical guideline. Arterial hypertension”. [Internet]. Kyiv: State Expert Centre of the Ministry of Health of Ukraine; [2023; cited 2023 May 11]. Available from: https://www.dec.gov.ua/wp-content/uploads/2019/11/kn_artergipert.pdf. Ukrainian.

Electronic document “Unified clinical protocol of primary, emergency and secondary (specialized) medical care. Arterial hypertension”. [Internet]. Kyiv: State Expert Centre of the Ministry of Health of Ukraine; [2023; cited 2023 May 11]. Available from: https://www.dec.gov.ua/wp-content/uploads/2019/11/384_2012ykpmd_ag.pdf. Ukrainian.

Unger T, Borghi C, Charchar F. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020;75: 1334-57. DOI: 10.1161/HYPERTENSIONAHA.120.15026. Epub 2020 May 6. PMID: 32370572. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.120.15026

Peacock E, Krousel-Wood M. Adherence to antihypertensive therapy. Med. Clin. North Am. 2017;101: 229-45. DOI: 10.1111/j.1751-7176.2008.07572.x DOI: https://doi.org/10.1016/j.mcna.2016.08.005

Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertension (Greenwich). 2008;10(5): 348-54. DOI:10.1111/j.1751-7176.2008.07572.x . DOI: https://doi.org/10.1111/j.1751-7176.2008.07572.x

Wang C, Yuan Y, Zheng M, Pan A, Wang M, Zhao M, et al. Association oage of onset of hypertension with cardiovascular diseases and mortality. J Am Coll Cardiol. 2020;75: 2921-30. DOI: https://doi.org/10.1016/j.jacc.2020.04.038

Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018; 36: 1953–2041 DOI: 10.1097/HJH.0000000000001940. Erratum in: J Hypertens. 2019 Jan;37(1):226. PMID: 30234752. DOI: https://doi.org/10.1097/HJH.0000000000001940

Guideline for the pharmacological treatment of hypertension in adults. Geneva: World Health Organization; 2021. Licence: CC BY-NC-SA 3.0 IGO

Pharmacist protocol for dispensing prescription drugs for the treatment of cardiovascular diseases that are subject to reimbursement. [Internet]. Kyiv: State Expert Centre of the Ministry of Health of Ukraine; [2023; cited 2023 May 11]. Available from: https://www.dec.gov.ua/wp-content/uploads/2022/01/2022_7_pf.pdf. Ukrainian.

Published

2023-09-11

How to Cite

Samohalska, O. Y., Shmanko, O. V., Mandziy, Z. P., Markiv, I. M., Tiurina, V. F., Meretska, I. V., … Halinchynska, Y. O. (2023). ANALYSIS OF PHARMACOTHERAPY OF ARTERIAL HYPERTENSION AT THE INPATIENT STAGE. Pharmaceutical Review Farmacevtičnij časopis, (2). https://doi.org/10.11603/2312-0967.2023.2.13871

Issue

Section

Pharmaceutical care