SUBSTANTIATION FOR THE CHOICE OF SUPPOSITORY BASE OF THE RECTAL SUPPOSITORIES WITH ANTI-INFLAMMATORY ACTIVITY
DOI:
https://doi.org/10.11603/2312-0967.2023.1.13562Keywords:
rectal suppositories, release, ibuprofen, cocoa butter, cetostearyl alcohol, WitepsolAbstract
The aim of the work. Theoretical and experimental substantiation for the choice of suppository base of the rectal anti-inflammatory suppositories with ibuprofen.
Materials and Methods. A study was conducted to select a hydrophobic base for the production of rectal suppositories with ibuprofen by pouring method. In order to study the rate of active pharmaceutical ingredient release from suppository samples, the membrane diffusion method through a semipermeable membrane was used. Samples of suppositories with ibuprofen based on Vitepsol and based on cocoa butter with cetostearyl alcohol were prepared.
A 0.1 M solution of hydrochloric acid was used as a dialysis medium, in which samples of suppositories based on Vitepsol and cocoa butter were placed. Sampling was carried out after 1, 2, 3, 4, 5 and 6 hours. Absorption spectrophotometry in the UV-region of the spectrum was used to study the amount of active pharmaceutical ingredient released.
Results and Discussion. According to the obtained data of experimental research, both bases, cocoa butter: cetostearyl alcohol, and Vitepsol, had almost the same indicators of ibuprofen release, but we chose the cocoa butter base, which is of natural origin, as rational.
Conclusions. On the basis of the conducted experimental research, the choice of the suppository base of extemporaneous rectal suppositories was studied and substantiated; the quality indicators of rectal suppositories with ibuprofen were studied in accordance with the methods given in SPhU 2.0.
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